Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Designing vaccines by computer

13.04.2005


Having vaccines developed by computer may sound unnerving but the increasing role of computer modelling in the development of new vaccines could bring new products onto the market quicker, benefiting patients and saving pharmaceutical companies millions of pounds.



Researchers using informatics and computer modelling can help scientists to uncover and harness the hidden patterns in the wealth of DNA and protein sequences that modern bioscience generates and cut the number of compounds drug companies need to test when searching for new vaccines.

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at the Edward Jenner Institute for Vaccine Research are using a very simple concept to help speed up the development of vaccines. They are studying fragments of ’foreign’ proteins that have been shown by experiments to effectively trigger a response by the immune system. They look for common patterns in their sequences or structures and use the information to create a theoretical model of what is needed for one of these fragments to trigger an immune response. They can then employ computers to search for similar sequences in the thousands of sequences now available. When the search finds something promising it can be experimentally tested to see if it will trigger a response.


Dr Darren Flower, an international leader in this work, said, "A crucial feature of this search strategy is that we don’t have to know what a foreign protein actually does in order to identify it as having fragments that that could make good vaccines. This approach has the potential to significantly reduce the number of proteins that we need to experimentally test to develop new vaccines to protect both humans and economically important livestock."

Professor Nigel Brown, BBSRC Director of Science and Technology, said, "Predictive biology, such as this work, has the potential to bring vaccines and medicines to patients faster, and may also offer the potential to re-model existing vaccines to see whether they can regain their effectiveness against viruses and bacteria that have evolved resistance."

Matt Goode | EurekAlert!
Further information:
http://www.bbsrc.ac.uk

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>