Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sensory deprivation reduces new cell size in the olfactory system

07.04.2005


Sensory deprivation causes changes in new cell size and excitability in the olfactory system, which governs the ability to smell, according to a study in Neuron by a Yale School of Medicine researcher.



"This gives new insight into how stem cells in the olfactory system may be used to restore function in a brain that has been compromised by degenerative disease or trauma," said Gordon Shepherd, M.D., co-author of the paper and professor of neuroscience at Yale.

Shepherd, on sabbatical with Pierre-Marie Lledo of the Pasteur Institute, investigated how the olfactory system responds to changes brought about by injury or different levels of activity. They closed one nostril in mice, a common sensory deprivation procedure, and then observed how the olfactory system adjusted to the change in sensory input.


The olfactory system is one of the most plastic regions of the brain, with nerve cells that are continually replenished by stem cells. Stem cells in the nose replenish the sensory cells, which send the odor messages to the olfactory bulb. "There also are stem cells deep in the brain that replenish the interneurons, which carry out much of the processing of the odor messages that takes place in the olfactory bulb," Shepherd said.

When deprived of sensory input, there was a reduction in the size of the new interneurons, but this was compensated by an increase in their excitability. Shepherd and colleague Michele Migliore, visiting scientist from Palermo, Sicily, carried out simulations which showed how these two changes balance each other. "This preserves the function of the interneurons in being able to process input if it were to be restored," Shepherd said.

In another recent study, Shepherd and Migliore extended their model to show how processing takes place within the olfactory networks. The new data on plasticity will be incorporated into the new model.

In addition to Shepherd and Migliore, co-authors included Armen Saghatelyan, Pascal Roux, Christelle Rochefort, David Desmaisons and Pierre Charneau of the Pasteur Institute.

Jacqueline Weaver | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>