Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists discover way to control allergic reactions

06.04.2005


Scientists have discovered a novel method to reduce cat allergic reactions by topping up the immune cells responsible for controlling them.



According to research published this week in the Public Library of Science (PLoS) Medicine, the team from Imperial College London and Royal Brompton Hospital have discovered a way to decrease allergic reactions by increasing numbers of CD4+ regulatory T-cells.

Dr Mark Larché from Imperial College London and Royal Brompton Hospital, and senior author comments: "This discovery is a hugely important step in our understanding of how immunity and inflammation play a role in allergic reactions. Although we have known about the role of these regulatory immune cells for a number of years, this is the first time we have found a way to manipulate them to help control allergic reactions."


There are a number of types of T-cells in the body including T-helper 1, which are important in autoimmune diseases, T-helper 2, which are important in allergies, and T-regulatory cells. In allergic diseases, the body produces too many T-helper 2 cells, and not enough T-regulatory cells. This can result in asthma, hayfever and allergic eczema.

The researchers discovered that by increasing the levels of CD4+ T-regulatory cells they were able to control the extent of the allergic inflammation. They injected cat allergen synthetic peptides into volunteers to stimulate the growth of the regulatory cells, and found the extent of the allergic reaction was reduced.

At the same time, this discovery could also have implications for autoimmune diseases such as type 1 diabetes and multiple sclerosis. Autoimmune diseases arise when too many T-helper 1 cells are produced against one’s own body. With this approach, it may be possible to stop or limit these diseases.

Professor Barry Kay from Imperial College London and Royal Brompton Hospital, and author on the paper, adds: "This is an important step in our understanding of how to treat allergic disease. Allergies are becoming increasingly common, and in may cases, progressively more difficult to manage. This discovery could be crucial in helping to alleviate the worst effects."

To date the team have carried out these studies in small groups of volunteers, but over the summer they are looking to organise a much larger clinical trial in conjunction with Circassia, a company spun out from Imperial.

Tony Stephenson | EurekAlert!
Further information:
http://www.imperial.ac.uk

More articles from Life Sciences:

nachricht Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Structured light and nanomaterials open new ways to tailor light at the nanoscale

23.04.2018 | Physics and Astronomy

On the shape of the 'petal' for the dissipation curve

23.04.2018 | Physics and Astronomy

Clean and Efficient – Fraunhofer ISE Presents Hydrogen Technologies at the HANNOVER MESSE 2018

23.04.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>