Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists discover way to control allergic reactions

06.04.2005


Scientists have discovered a novel method to reduce cat allergic reactions by topping up the immune cells responsible for controlling them.



According to research published this week in the Public Library of Science (PLoS) Medicine, the team from Imperial College London and Royal Brompton Hospital have discovered a way to decrease allergic reactions by increasing numbers of CD4+ regulatory T-cells.

Dr Mark Larché from Imperial College London and Royal Brompton Hospital, and senior author comments: "This discovery is a hugely important step in our understanding of how immunity and inflammation play a role in allergic reactions. Although we have known about the role of these regulatory immune cells for a number of years, this is the first time we have found a way to manipulate them to help control allergic reactions."


There are a number of types of T-cells in the body including T-helper 1, which are important in autoimmune diseases, T-helper 2, which are important in allergies, and T-regulatory cells. In allergic diseases, the body produces too many T-helper 2 cells, and not enough T-regulatory cells. This can result in asthma, hayfever and allergic eczema.

The researchers discovered that by increasing the levels of CD4+ T-regulatory cells they were able to control the extent of the allergic inflammation. They injected cat allergen synthetic peptides into volunteers to stimulate the growth of the regulatory cells, and found the extent of the allergic reaction was reduced.

At the same time, this discovery could also have implications for autoimmune diseases such as type 1 diabetes and multiple sclerosis. Autoimmune diseases arise when too many T-helper 1 cells are produced against one’s own body. With this approach, it may be possible to stop or limit these diseases.

Professor Barry Kay from Imperial College London and Royal Brompton Hospital, and author on the paper, adds: "This is an important step in our understanding of how to treat allergic disease. Allergies are becoming increasingly common, and in may cases, progressively more difficult to manage. This discovery could be crucial in helping to alleviate the worst effects."

To date the team have carried out these studies in small groups of volunteers, but over the summer they are looking to organise a much larger clinical trial in conjunction with Circassia, a company spun out from Imperial.

Tony Stephenson | EurekAlert!
Further information:
http://www.imperial.ac.uk

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Can we see monkeys from space? Emerging technologies to map biodiversity

23.06.2017 | Information Technology

Understanding animal social networks can aid wildlife conservation

23.06.2017 | Ecology, The Environment and Conservation

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>