Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ingredient in garlic protects against severe chronic pulmonary hypertension in rats

04.04.2005


Small daily doses of allicin, the active metabolic in garlic, proved effective in preventing a severe form of pulmonary hypertension in rats, according to a study reported Saturday, April 2 by University of Alabama at Birmingham researchers at the Experimental Biology 2005 meeting in San Diego. The human form of the disease – primary pulmonary hypertension – often leads to cardiovascular complications such as right heart hypertrophy and failure and is frequently lethal.



Dr. David D. Ku says the findings confirm an earlier study by the team that garlic protects against a less lethal form of acute pulmonary hypertension in rats. The new study by Ku, graduate student Hsien Chin Wu and research assistant Xiaowei Sun, not only looks at a chronic form of the disease but also goes a big step further by pinpointing the effective ingredient in garlic and demonstrating that it achieves its protective effects through vasorelaxation.

The presentation at Experimental Biology 2005 was part of the scientific sessions of the American Society for Pharmacology and Experimental Therapeutics.


In the UAB study, rats were given a single dose of monocrotaline, a well-established mechanism for inducing vasoconstriction of the pulmonary arteries. Within three weeks, half the rats had developed chronic pulmonary hypertension, with markedly increased pulmonary arterial pressure, just as expected. But the other half experienced no such increase. These rats had received the hypertension-causing drug but their diets also had been supplemented daily for three weeks with small doses of allicin. And it was the allicin, not the garlic itself that protected the supplemented rats from developing the disease, emphasizes Dr. Ku. Animals that consumed garlic from which the active metabolite had been removed or inactivated with heat experienced no benefit.

In a separate but related study also presented at Experimental Biology 2005, in the scientific sessions of the American Society for Pharmacology and Experimental Therapeutics, Dr. Ku’s team found that garlic treatment also could protect coronary vascular function and lessen the severity of right heart hypertrophy, two of the serious byproducts of chronic pulmonary hypertension.

Garlic has long been thought to have medicinal properties, and reports have suggested that garlic supplementation in humans could help lower blood pressure, decrease ischemic injury, reduce serum cholesterol, inhibit platelet function and enhance thrombolysis. Garlic also has been suggested to improve arterial oxygenation associated with pulmonary dysfunction in patients with hepatopulmonary syndrome. However, obtaining concrete scientific data to substantiate many of these claims has remained elusive, notes Dr. Ku, in part because it has been difficult to accurate detect and quantify the active garlic metabolite.

Recently the UAB team developed a new highly effective method for doing just that, for quantifying the actual amount of metabolite included in treatments. In what the researchers describe as a "very simple" analytical method, reversed-phased high performance liquid chromatograph method is coupled to mass spectrometry with multiple ions reaction monitoring. Using this method, the team has been able to demonstrate that varying concentrations of garlic active metabolite from either pure allicin, freshly crushed garlic, or commercial freeze-dried garlic preparations, directly correlate to the extent of their vasorelaxation/vasodepressor responses in isolated pulmonary arteries and in living animals.

What does this mean for human diets? Dr. Ku says studies are needed to prove similar beneficial effects from the allicin in garlic will occur in humans – his new method should make such studies a little easier – but in view of the low toxicity associated with eating garlic, including garlic in one’s daily food intake seems a reasonable approach, especially for people with respiratory and pulmonary ailments. The amount of garlic that delivered the protective effects to the rats in his study was the equivalent, for humans, of two cloves of garlic a day.

Sarah Goodwin | EurekAlert!
Further information:
http://www.faseb.org

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>