Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NIH skate choice follows MDI Bio Lab white paper

21.03.2005


With the National Institutes of Health announcing recently that the genome of the skate is going to be sequenced, the Mount Desert Island Biological Laboratory is poised to play an important role in this large-scale project.



The decision to fund the sequencing of the skate was in response to a proposal submitted by MDIBL, the Genome Sequencing Center of Washington University School of Medicine in St. Louis and the Benaroya Institute in Seattle. Approval came from the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health.

The skate is one of 11 strategically selected non-mammalian organisms determined by a NHGRI panel to have the greatest potential to fill crucial gaps in human biomedical knowledge. According to Dr. Mark S. Guyer, Director of NHGRI’s Division of Extramural Research, "The most effective approach we currently have to identify the essential functional and structural components of the human genome is to compare it with the genomes of other organisms."


It has been shown that most human genome sequences originated long before humans themselves. Consequently, scientists will use the genomes of non-mammalian animals to learn more about how, when and why the human genome came to be composed of certain DNA sequences, as well as to gain new insights into organization of genomes. In addition, many of these organisms can shed light on human disease by systematically discovering causes compared to finding them by chance.

The skate, a member of the elasmobranch family, is one of the oldest vertebrate organisms, dating back 450 million years. Elasmobranchs (sharks, skates and rays) were one of the first primitive vertebrate species to develop a jaw, an important step on the evolutionary ladder.

For more than 100 years the MDIBL has served as a world leader in elasmobranch research. As one of only four Marine and Freshwater Biomedical Science Centers in the United States designated by the National Institute of Environmental Health Sciences, MDIBL has been home to scores of scientific experts utilizing sharks and skates to better understand human physiology, toxicology, immunology, stem cell and cancer biology, and neurobiology.

Dr. David Barnes, Senior Scientist and Associate Director of the Center for Marine Functional Genomic Studies at MDIBL said, "MDIBL is one of only a handful of research institutions in the world that specializes in elasmobranch research. Scientists here have been using the skate as a model since the early 1920’s and are largely responsible for development of the skate as a model organism for human disease. The result is that we have a high concentration of information and expertise on elasmobranch organisms and are well positioned to support this important initiative."

Data from the skate sequencing project will be integrated into MDIBL’s Comparative Toxicogenomics Database, an interactive database designed to assist scientists worldwide in comparing genetic information from more than 40,000 species in an effort to better understand genetic susceptibility to environmental toxins and disease.

"The decision to sequence the skate genome is an enormous step forward in the emerging field of marine functional genomics," said John N. Forrest, Jr., MD, Director of MDIBL. "Elasmobranch genomes hold many important clues to understanding the genes involved in development and disease. All of us at MDIBL are very pleased that the tremendous research potential of the skate will now be realized."

Grady Holloway | EurekAlert!
Further information:
http://www.ctd.mdibl.org

More articles from Life Sciences:

nachricht Kidney tumor: Genetic trigger discovered
18.06.2018 | Julius-Maximilians-Universität Würzburg

nachricht New type of photosynthesis discovered
18.06.2018 | Imperial College London

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Novel method for investigating pore geometry in rocks

18.06.2018 | Earth Sciences

Diamond watch components

18.06.2018 | Process Engineering

New type of photosynthesis discovered

18.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>