Eleven leading biomedical organizations announced today the formation of a unique $18M, three-year public-private consortium to create a comprehensive library of gene inhibitors to be made available to the entire scientific community. Based on the method of RNA interference (RNAi), this library will give scientists worldwide the tools to knock down expression of virtually all human and mouse genes, accelerating the growth of basic knowledge of gene function in normal physiology and disease.
Called The RNAi Consortium (TRC), the collaborative effort is based at the Broad Institute of MIT and Harvard, and includes six MIT- and Harvard-associated research institutions and five international life sciences organizations.
The goal of TRC is to use the recently discovered RNAi mechanism to create widely applicable research reagents composed of short RNA hairpin sequences carried in lentiviral vectors. These can be used in a wide range of cellular and animal studies to discover the key genes underlying normal physiology and diseases – including cancer, diabetes and immunological responses. TRC will not only create and validate these reagents, but will make them available to scientists worldwide through commercial and academic distributors.
Michelle Nhuch | EurekAlert!
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