If you have ever covered a flashlight with your hand and seen the red light that still comes through, then you have seen light in the therapeutic window – that magic wavelength that is not absorbed or reflected away by tissue. Scientists believe that they can use light at that wavelength to signal manmade molecules to release drugs at disease sites in the body.
Such possibilities will be discussed in a poster and a talk by Virginia Tech researchers presenting at the 229th American Chemical Society national meeting in San Diego on March 13-17.
Researchers in Karen Brewers group at Virginia Tech have designed supramolecular complexes that can hold and, when signaled by light (photoinitiatied), will generate pharmaceutical compounds that can cleave DNA, such as in a tumor cell. "The challenge has been that tissue blocks light so we cant signal molecules deep within the body to deliver drug therapy," says Brewer, associate professor of chemistry.
Susan Trulove | EurekAlert!
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