Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

More than 300 new hypertension genes discovered

07.03.2005


A genome-wide scan in hypertension in the East Finland founder population has re-affirmed the majority of genes previously known to be associated with hypertension. The new genes discovered include also ones, which appear to give humans a strong protection against hypertension. The scan was conducted by a novel approach.



The DNA samples used in the study were collected in the 1980’s from a genetically-homogeneous population that can be accurately traced back to a few hundred founders in the 1600’s.

The Jurilab team used a novel approach. The Jurilab gene discovery team typed over 100,000 single-nucleotide-polymorphisms covering the majority of structural blocks in the genome of Eastern Finns, who share exceptionally large genomic regions. The study was supported by Tekes and carried out in collaboration with the University of Kuopio in East Finland.


The study confirms Jurilab’s previous assumptions concerning the total number of disease-related genes involved in hypertension, and gives invaluable insight into the interplay of different genes and new pathways in hypertension.

"These discoveries open up a new chapter in the development of predictive tests and much improved therapeutics for hypertension", said professor Jukka T. Salonen, Jurilab’s chief scientific officer. "We have also shown that human studies are relevant and cannot be replaced by animal models".

"Jurilab plans to commercialize the findings rapidly with our partners starting with the first hypertension molecular diagnostic test and followed by other exciting products in diagnostics and drug development", said Kari Paukkeri, CEO of the company.

Hypertensions prevalence rising

Between a quarter and a third of adults in developed countries suffer from hypertension, and this prevalence is on the rise. Hypertension starts to damage the heart, arteries, brains and kidneys already in childhood but is detectable by blood pressure measurements at the earliest in the adulthood.

Also, most current antihypertensive drugs are not usable by all hypertension patients because of lack of efficacy and adverse reactions. As these differences between individuals are of genetic origin, molecular diagnostic tests can help the physician to start treatment early and to select the drug of choice without the expensive and harmful trial-and-error method.

Mira Banerjee | alfa
Further information:
http://www.tekes.fi

More articles from Life Sciences:

nachricht Repairing damaged hearts with self-healing heart cells
22.08.2017 | National University Health System

nachricht Biochemical 'fingerprints' reveal diabetes progression
22.08.2017 | Umea University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>