Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

More than 300 new hypertension genes discovered

07.03.2005


A genome-wide scan in hypertension in the East Finland founder population has re-affirmed the majority of genes previously known to be associated with hypertension. The new genes discovered include also ones, which appear to give humans a strong protection against hypertension. The scan was conducted by a novel approach.



The DNA samples used in the study were collected in the 1980’s from a genetically-homogeneous population that can be accurately traced back to a few hundred founders in the 1600’s.

The Jurilab team used a novel approach. The Jurilab gene discovery team typed over 100,000 single-nucleotide-polymorphisms covering the majority of structural blocks in the genome of Eastern Finns, who share exceptionally large genomic regions. The study was supported by Tekes and carried out in collaboration with the University of Kuopio in East Finland.


The study confirms Jurilab’s previous assumptions concerning the total number of disease-related genes involved in hypertension, and gives invaluable insight into the interplay of different genes and new pathways in hypertension.

"These discoveries open up a new chapter in the development of predictive tests and much improved therapeutics for hypertension", said professor Jukka T. Salonen, Jurilab’s chief scientific officer. "We have also shown that human studies are relevant and cannot be replaced by animal models".

"Jurilab plans to commercialize the findings rapidly with our partners starting with the first hypertension molecular diagnostic test and followed by other exciting products in diagnostics and drug development", said Kari Paukkeri, CEO of the company.

Hypertensions prevalence rising

Between a quarter and a third of adults in developed countries suffer from hypertension, and this prevalence is on the rise. Hypertension starts to damage the heart, arteries, brains and kidneys already in childhood but is detectable by blood pressure measurements at the earliest in the adulthood.

Also, most current antihypertensive drugs are not usable by all hypertension patients because of lack of efficacy and adverse reactions. As these differences between individuals are of genetic origin, molecular diagnostic tests can help the physician to start treatment early and to select the drug of choice without the expensive and harmful trial-and-error method.

Mira Banerjee | alfa
Further information:
http://www.tekes.fi

More articles from Life Sciences:

nachricht Show me your leaves - Health check for urban trees
12.12.2017 | Gesellschaft für Ökologie e.V.

nachricht Liver Cancer: Lipid Synthesis Promotes Tumor Formation
12.12.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>