Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm

04.03.2005


Mayo Clinic researchers have discovered a genetic marker that may pave the way for a fast, inexpensive blood test to predict one type of deadly stroke that strikes 30,000 people in the United States annually.



The article and an editorial appear in the March edition of the Journal of Neurosurgery, http://www.thejns-net.org/jns/issues/toc_pre.html. The Mayo Clinic researchers report that people with key variations in a gene that affects the ability of blood vessels to relax are 10 times more likely to suffer a stroke from a ruptured brain aneurysm than people who have aneurysms but lack these key genetic variations.

"There are an incredible number of people walking around with brain aneurysms, but only a small percentage of these aneurysms will rupture," says G. Vini Khurana, M.D., Ph.D., the Mayo Clinic neurosurgical researcher who led the study. "There has been a search for a marker that would identify patients with rupture-prone aneurysms for a very long time because this disease can strike like lightning. Rupture typically happens suddenly and completely unexpectedly -- and when it does at least half of patients die or suffer long-term disability. That’s why our results suggesting that we may have found such a marker are so exciting: there is an urgent public health need for it."


Significance of the Mayo Clinic Research

The Mayo Clinic researchers conclude that they have found the first genetic marker to help doctors identify which cases of a condition known as sporadic brain aneurysm are at highest risk for death and disability due to rupturing and subsequent bleeding into the brain. Sporadic brain aneurysm is a different medical condition from familial aneurysm, for which genetic markers are already known. However, approximately 90 percent of all cases of aneurysm -- a dangerous thinning of blood vessel walls in the brain -- fall into the "sporadic" category. While development of sporadic brain aneurysm is relatively common (as autopsies have shown) many people have them and have no symptoms or warning signs that they could be at risk of catastrophic rupture that is imminently life endangering.

The Key Finding

The Mayo researchers are the first to identify specific genetic variations or "polymorphisms" associated with an approximately 10-fold increased risk of a ruptured aneurysm. If further studies validate these findings, screening for these polymorphisms could be done with a fast, inexpensive blood test to predict which patients with aneurysms are at risk. The experimental blood test researchers developed detects specific variations in the gene that encodes an important blood vessel-relaxation protein.

Dr. Khurana notes that the Mayo Clinic group’s effort is just the beginning of their research. Their hope is that a large, multicenter and international clinical trial will test their results. "But our initial results are really very powerful," he adds. "Our findings have very strong implications for brain aneurysm research. I think from a public health point of view, if you consider the millions and millions of dollars that go to sorting out this lightning-like, catastrophic disease, every year in the United States alone there are potentially 30,000 people who could be affected by this."

Background Biology

Physicians and researchers have long been puzzled by the discrepancy between the large numbers of people with brain aneurysms -- 10 to 15 million people in the U.S. -- and the incidence of aneurysms rupturing in a relatively small fraction of those people. Doctors knew some aneurysms were more prone to rupture, but didn’t know why. They suspected genes played a role, but lacked convincing studies supporting this hypothesis.

The Mayo Clinic research team had previously done extensive work with a molecule (nitric oxide synthase) known to play a pivotal role in the endothelium. The endothelium is the lining of the blood vessels that is very important to maintaining smooth blood flow. Disrupted blood flow in brain arteries is associated with increased risk of stroke. The Mayo team’s previous work showed that when the amount of this molecule is increased using a gene therapy approach, the arteries relax and maintain smooth, healthy flow.

The Investigation

To determine the role of nitric oxide synthase gene variations in ruptured brain aneurysms, the Mayo Clinic team screened the genetic variants of 49 patients who had unruptured brain aneurysms, and compared them with the genetic variants of 58 emergency room patients with ruptured aneurysms.

Blood samples were taken from all, and DNA analysis performed. There was no significant difference between the two groups in terms of age, race, gender, health history, family history, and smoking habits. Despite these similarities, the genetic differences were striking. Says Dr. Khurana: "Our findings are the first to present strong evidence that the reason for sporadic brain aneurysm rupture may be genetic."

Collaborators and Support

In addition to Dr. Khurana, other Mayo Clinic collaborators include: Irene Meissner, M.D.; Youvraj Sohni, Ph.D.; William Bamlet; Robyn McClelland, Ph.D.; Julie Cunningham, Ph.D.; and Fredric Meyer, M.D. Their work was supported by the Departments of Neurologic Surgery and Neurology, Mayo Clinic and Mayo Foundation.

Bob Nellis | EurekAlert!
Further information:
http://www.mayoclinic.com

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>