Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment for inflammatory bowel disease

02.03.2005


An anti-inflammatory therapy utilizing proteins called type 1 interferon IFN-alpha and IFN-beta (IFN-á/â) has been shown by researchers at the University of California, San Diego (UCSD) School of Medicine and their colleagues in Japan and Israel to offer relief in mouse models of Crohn’s disease and ulcerative colitis, the two major forms of the painful, chronic condition called inflammatory bowel disease (IBD) that affects nearly 1 million Americans.



Published in the March 2005 issue of the Journal of Clinical Investigation (JCI), the study provides the first description of the molecular mechanism by which IFN-á/â inhibits the severity of colitis and maintains intestinal homeostasis, or the "constant state" of the gut, by suppressing pro-inflammatory activity by the immune system macrophages. "Although IFN-á/â therapy has been tried in recent clinical trials, along with other anti-inflammatory treatments, researchers have not understood how or why IFN-á/â might work as an IBD treatment," said Eyal Raz, M.D., UCSD professor of medicine and the study’s senior author. "Our study describes how activated IFN-á/â plays a protective role in colonic inflammation."

The study’s first author, Kyoko Katakura, M.D, Department of Medicine II, Fukushima, Japan, added that the team’s results point to an important protective and potential therapeutic role for IFN-á/â. In an accompanying Commentary in the March issue of JCI, German researchers Stefan Wirtz and Markus F. Neurath noted that the results "suggest that strategies to modulate innate immunity may be of therapeutic value." They added that "It is astonishing to realize that in spite of the existence of clinical trials on the use of IFN-á/â in the treatment of UC (ulcerative colitis), there is only very limited information about their expression and biological function in the immune system of the gut."


The Raz team discovered the role of IFN-á/â through their continuing studies of an immune system molecule called Toll-like receptor 9 (TLR9). In previous research* the researchers had shown that TLR9 initiated an anti-inflammatory program to ease colitis in experimental animals. In the new study, the investigators again utilized mouse models to explore how TLR9 eases inflammation. This time, however, they found differing reactions in two strains of mice. Agents that activate TLR9 were given to the two different groups of mice that appear similar, but are from strains that make them genetically different. The TLR9 activators given to one of the groups, called RAG mice, inhibited the severity of experimental colitis, but had no effect on the other group of mice, called SCID mice.

To understand why the mice reacted differently, the researchers used a variety of scientific approaches to explore the cellular and molecule events that caused one strain to respond to therapy and the other to be resistant. They determined that TLR9-induced protection occurs when the proteins IFN-á/â were activated. The resistance to protection in the SCID mice was due to a mutation that impairs IFN-á/â signaling in these mice. Additional experiments with mice developed without IFN-á/â further verified the proteins’ role in intestinal homeostasis.

Sue Pondrom | EurekAlert!
Further information:
http://www.ucsd.edu

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>