Nose cells provide a window into the brain
In the first study to examine living nerve cells from patients with psychiatric disease, scientists from the Monell Chemical Senses Center, the University of Pennsylvania, and collaborating institutions report altered nerve cell function in olfactory receptor neurons from patients with bipolar disorder. Like other psychiatric and neurodegenerative disorders, bipolar disorder affects nerve cells in the brain, making it difficult to study underlying neurobiological causes of the disease during its actual course. According to senior author Nancy Rawson, PhD, a Monell cellular biologist, "Previous studies have used non-nerve cells, such as fibroblasts or red blood cells, to examine how cells function in patients with bipolar disorder. But since this is a psychiatric disorder, we need to understand what’s going on in nerve cells."
Olfactory receptor neurons (ORNs), located in a small patch of epithelium inside the nose, are nerve cells that contain receptors for the thousands of odorant molecules detected by humans. Easily obtained using a simple 5-minute biopsy procedure, ORNs share many characteristics with nerve cells in the brain. These features make ORNs a useful model to study the neural effects of psychiatric disease. Calcium is integral to properly-functioning nerves, and previous studies have implicated dysfunctions of cellular calcium metabolism as a contributing factor to bipolar disorder. Changes in how much calcium is inside ORNs and other nerve cells tell researchers how the nerves respond to stimulation.
Leslie Stein | EurekAlert!
Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel
The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering