Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

TGen and Kronos initiate Alzheimer’s disease study

24.02.2005


Researchers have unprecedented chance to search for Alzheimer’s susceptibility genes and develop advanced clinical testing

Phoenix-Researchers at the Translational Genomics Research Institute (TGen) and Kronos Science Laboratories, an affiliate of Phoenix-based Kronos Optimal Health Company, have initiated a study with unprecedented power to identify genes that are involved in the development of Alzheimer’s disease, the most common form of disabling memory and thinking problems in older persons.

Using cutting edge technology, researchers at TGen will survey 570,000 letters of the genetic alphabet (commonly known as "SNPs") in the DNA of 1,000 deceased persons confirmed to have Alzheimer’s disease at autopsy and 1,000 deceased persons confirmed to be free of Alzheimer’s disease at autopsy.



Because of the number of SNPs surveyed-more than any surveyed ever before-researchers have an extraordinary opportunity to search for Alzheimer’s susceptibility genes throughout the human genome. "The technology to sift through the human blueprint at ultra-high resolution to get at the root of diseases such as Alzheimer’s has finally come of age," explains Dietrich A. Stephan, the study’s principal investigator and head of TGen’s Neurogenomics Division. "TGen is one of only a few places in the world that has this type of technology. The collaboration between Kronos and TGen represents a partnership which promises to greatly improve our understanding of the genetic causes of Alzheimer’s disease so we may diagnose it early and develop knowledge-based therapies."

Kronos Science Laboratories will have an exclusive worldwide license to all intellectual property that results from the research. Based upon the results of this study, Kronos will develop a test that aids in clinical diagnosis and can determine a person’s genetic predisposition for developing Alzheimer’s disease. "An estimated 4.5 million Americans are living with Alzheimer’s disease today, and that number is projected to more than triple by 2050," said Dr. Christopher Heward, President of Kronos Science Laboratories. "At Kronos, we are passionate about our healthy living and aging philosophy, and we’re pleased to demonstrate this commitment by participating in this unparalleled study that has the potential to make a significant impact in the lives of affected individuals and families."

To date, researchers have identified several rare genes that cause a form of Alzheimer’s disease resulting in memory and thinking problems before the age of 60. In addition, scientists have identified a common gene that accounts for about 30 percent of those who develop the symptoms of Alzheimer’s disease after the age of 60. The search is now on to discover other genes that contribute to the development of Alzheimer’s disease.

Researchers will obtain DNA samples from brain banks in the USA and Europe.

"We could not be more excited about the possibility of discovering the remaining genes involved in the development of Alzheimer’s disease," says the study’s other principal investigator, Dr. Eric Reiman, Clinical Director of the Neurogenomics Division at TGen, Director of the Arizona Alzheimer’s Disease Consortium, Professor of Psychiatry at the University of Arizona, and Scientific Director of the Positron Emission Tomography Center at Banner Good Samaritan Medical Center. "We hope that this information will improve our understanding of the disorder, provide targets against which to aim new treatments, and permit health care providers to identify those who might benefit from disease-slowing and prevention therapies at the earliest possible time."

The study is expected to cost approximately $6 million and will be jointly funded by TGen and Kronos. Researchers expect the study to be completed within 18 months.

Galen Perry | EurekAlert!
Further information:
http://www.tgen.org
http://www.kronoscompany.com

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>