Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sussex scientist makes MRSA treatment breakthrough with synthetic antibiotic

22.02.2005


A groundbreaking new treatment to combat the hospital killer bug MRSA, which is estimated to cause up to 5,000 deaths a year in Britain, is being developed by a University of Sussex scientist.



Philip Parsons, a professor of organic chemistry, has devised a simple "one-pot" method to make a synthetic version of a natural antibiotic, lactonamycin, which could be used to treat infected patients. He has now received a £280,000 grant from the Engineering and Physical Sciences Research Council towards developing a series of lactonamycin-like substances.

Professor Parsons explains: "The most important thing hospitals can do to fight MRSA is to improve ward cleanliness. But we still need new antibiotics to combat the bug when it arises. "We know that lactonamycin, a naturally occurring antibiotic, can kill MRSA. But it is has not been available as a drug therapy, partly due to its novelty and complexity. We are looking at a simple way to synthesise the antibiotic and its compounds, which could also be highly effective in the fight against infection."


The search for new antibiotics active against "super bugs" such as MRSA is of paramount importance because of the increasing problems faced by hospitals in treating drug-resistant bacterial infections. The latest Government figures estimate that up to 100,000 people catch an infection in UK hospitals every year, with the elderly and the very young most at risk of complications and death.

Research has shown that lactonamycin, an extract of the bacteria Streptomyces rishiriensis, is active against MRSA (methicillin-resistant Staphylococcus aureus).

Naturally occurring chemicals, such as lactonamycin, often have complex molecular structures and are difficult to synthesise because the process usually involves many chemical steps. Professor Parsons has discovered a "one-pot" method - known as cascade reaction - during which several reactions take place at once.

"This is a very exciting discovery," adds Professor Parsons. "It will be important not just for producing lactonamycin, but for making other compounds, natural products and drug substances more efficiently."

| alfa
Further information:
http://www.sussex.ac.uk

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>