Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sussex scientist makes MRSA treatment breakthrough with synthetic antibiotic

22.02.2005


A groundbreaking new treatment to combat the hospital killer bug MRSA, which is estimated to cause up to 5,000 deaths a year in Britain, is being developed by a University of Sussex scientist.



Philip Parsons, a professor of organic chemistry, has devised a simple "one-pot" method to make a synthetic version of a natural antibiotic, lactonamycin, which could be used to treat infected patients. He has now received a £280,000 grant from the Engineering and Physical Sciences Research Council towards developing a series of lactonamycin-like substances.

Professor Parsons explains: "The most important thing hospitals can do to fight MRSA is to improve ward cleanliness. But we still need new antibiotics to combat the bug when it arises. "We know that lactonamycin, a naturally occurring antibiotic, can kill MRSA. But it is has not been available as a drug therapy, partly due to its novelty and complexity. We are looking at a simple way to synthesise the antibiotic and its compounds, which could also be highly effective in the fight against infection."


The search for new antibiotics active against "super bugs" such as MRSA is of paramount importance because of the increasing problems faced by hospitals in treating drug-resistant bacterial infections. The latest Government figures estimate that up to 100,000 people catch an infection in UK hospitals every year, with the elderly and the very young most at risk of complications and death.

Research has shown that lactonamycin, an extract of the bacteria Streptomyces rishiriensis, is active against MRSA (methicillin-resistant Staphylococcus aureus).

Naturally occurring chemicals, such as lactonamycin, often have complex molecular structures and are difficult to synthesise because the process usually involves many chemical steps. Professor Parsons has discovered a "one-pot" method - known as cascade reaction - during which several reactions take place at once.

"This is a very exciting discovery," adds Professor Parsons. "It will be important not just for producing lactonamycin, but for making other compounds, natural products and drug substances more efficiently."

| alfa
Further information:
http://www.sussex.ac.uk

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>