Findings could help with design of combination products that are not compromised by adverse host responses
Medical devices are traditionally thought of as fairly simple implants such as stents and hip replacements - pieces of plastic or metal that are placed in the body to handle a very specific function. But biomedical devices now on the drawing board are considerably more sophisticated and represent an unprecedented melding of man and machine.
Combination products, devices that include a combination of drug, biological and device components, are expected to be the next big thing in biomedical devices. An example of a combination product is a tissue-engineered device that combines living cells with a polymer scaffold. When implanted into a patient, the device can replace or restore damaged tissue or organ function. While the response of the body to each component is well known, considerably less is known about how their new union may affect the body’s reaction to a combination device.
Megan McRainey | EurekAlert!
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