Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Large DNA microarray dataset is made publicly available by LGC and the European Bioinformatics Institute (EBI)

18.02.2005


As the next phase of DTI’s Measurements for Biotechnology (MfB) programme to 2007 gets underway, a large DNA microarray dataset generated by an LGC-led consortium during the first phase is now freely available online at ArrayExpress, a leading public repository managed by the European Bioinformatics Institute (EBI). The sharing of well-annotated data is a primary objective of the Microarray Gene Expression Data (MGED) Society and this repository is stored in accordance with MGED recommendations.



Since the mid-1990s, DNA microarray technology has developed into a major tool for the investigation of global gene expression for all aspects of human disease. The technology is currently being explored for its efficacy in genomic approaches to toxicology. As toxicity is still the major cause of failure in clinical trials, there is strong industry interest in improved models for predictive toxicology.

Dr Carole Foy of LGC’s Bio-Molecular Innovation group said: "This dataset is a significant milestone from the MfB project, ‘Comparability of gene expression measurements,’ completed in 2004. It is a tribute to everyone involved in the consortium - NPL, Human Genome Mapping Project, Oxford Biomedica, Renovo and Royal London Hospital - that other scientists and analysts can now access this valuable data.


"So that the performance of microarrays can be maximised, LGC is working with the EBI in the current MfB programme on the project, ‘Toxicogenomics: Quality metrics for improving microarray based measurements,’ under the new Gene Measurement theme," she added.

The dataset produced by the LGC-led consortium relates to four commercially available arrays that probe the human genome, with between 4,000 and 30,000 genes probed per array. LGC measured gene expression status on 24 replicate arrays for each manufacturer, comparing a brain sample to a universal reference sample. NPL then contributed to the subsequent data analysis and normalisation in which nearly 700 text files containing well over eight million rows of microarray data were created. The dataset can be accessed at www.ebi.ac.uk/arrayexpress.

Imelda Topping | alfa
Further information:
http://www.lgc.co.uk
http://www.bioindustry.org
http://www.ebi.ac.uk/arrayexpress

More articles from Life Sciences:

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

nachricht Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>