Dartmouth Medical School geneticists have found links in the cell death machinery of worms and mammals, opening new avenues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases.
The work, reported in the February 17 issue of Nature, demonstrates the role of mitochondria, the cellular power plant, in prompting worm cells to self destruct. These results unify cell death models along the evolutionary spectrum, from simple animal systems to humans. In spite of its name, programmed cell death, or apoptosis, is essential for life; its needed for nervous system development and it keeps the body up and running. Miscues and failures are instrumental in cancer, autoimmune disorders or neurodegenerative diseases.
Mitochondria, the organelles responsible for producing energy to fuel cell processes, also appear to release molecules that set the cell death program in motion. While their activity in mammalian cell death was known, mitochondrial involvement in worms had not previously been shown.
Hali Wickner | EurekAlert!
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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