Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lactose malabsorption related to bone fractures in old age?

16.02.2005


Finnish researchers have discovered an interesting link between lactose malabsorption and the occurrence of bone fracture in elderly people.



It was three years ago that the Finnish researchers first identified a change affecting a single alkali in the human genome related to primary lactose malabsorption. The change is the conversion of cytosine to thymidine (genotype C/T) and it makes a person tolerate lactose for the rest of his/her life. Without this genetic change (genotype C/C), the activity of the lactase enzyme in small intestine mucosa is reduced at the age of 5 to 12 years on average, causing a deterioration of lactose tolerance.

Published in January and conducted by researchers from the Universities of Helsinki and Kuopio and the National Public Health Institute, the study investigated the relation between the genotype associated with lactose malabsorption and the occurrence of bone fracture in the elderly. The study included 483 elderly people in the City of Vantaa – 377 women and 106 men – all over 85 years of age.


The results proved that those with the genotype associated with lactose malabsorption (C/C) had substantially more hip and wrist fractures than those with the genotypes that produce life-long lactose tolerance (C/T or T/T).

The connection between C/C genotype and fractures was also detected in people who had never had symptoms of lactose intolerance despite having consumed dairy products all their lives. “It seems that even if people with this genotype consume dairy products, their bodies really cannot benefit from them,” says study author Irma Järvelä from the University of Helsinki.

The result was a surprise to the researchers because it was at odds with the results of a corresponding study completed last year on young men, according to which the genetic change associated with lactose tolerance had no connection with the bone density of the young men or their stress fractures.

Järvelä thinks that effect of the genetic change advances slowly and can only be seen in old age. However, more research will be needed to confirm this, she says.

Paivi Lehtinen | alfa
Further information:
http://www.helsinki.fi

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>