Developing compounds to block activation pathway
Researchers from Tufts-New England Medical Center have identified a long-sought-after enzyme that interacts with a specific protease-activated receptor, PAR1, on breast cancer cells. The study authors identified metalloprotease-1 as the molecular scissors that activates PAR1 resulting in cancer cell invasion and tumor growth. They were able to block the spread of the breast cancer in animals using novel compounds called pepducins that act on the inside surface of the cell downstream of the enzyme and receptor. Their study appears in the February 11 edition of the journal Cell.
PARs are a unique class of receptors that have long been known to play critical roles in blood clotting, inflammation and growth of blood vessels. More recently, PAR1 has been linked with the invasive and metastatic properties of many different kinds of cancers, however, it was not known how the receptor was being activated in tumors.
Heidi Hardman | EurekAlert!
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Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
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