The Protein Structure Initiative (PSI), a national program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines.
Crystal structure of a protein with unknown function from Leishmania major, a parasite of the human immune system.
The PSI is a 10-year, approximately $600 million project funded largely by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The first half of this project—a pilot phase that started in 2000—has centered on developing new tools and processes that enable researchers to quickly, cheaply, and reliably determine the shapes of many proteins found in nature.
"One thousand protein structures is a significant milestone for the PSI, and it shows an impressive return on the investment in the technology and methods for rapid structure determination," said Jeremy M. Berg, Ph.D., director of NIGMS. "These structures are interesting in their own right and provide the basis for modeling many important proteins."
The Structural Genomics of Pathogenic Protozoa Consortium, http://www.sgpp.org/
The TB Structural Genomics Consortium, http://www.doe-mbi.ucla.edu/TB/
The pilot phase of the PSI will end in mid-2005. Centers for the second phase will be announced in July 2005.
In addition to NIGMS, the PSI currently receives funding from the National Institute of Allergy and Infectious Diseases, a component of the National Institutes of Health.
For more information about the PSI, please visit http://www.nigms.nih.gov/psi/. To schedule an interview with Jeremy M. Berg, Ph.D., or John Norvell, Ph.D., please contact the NIGMS Office of Communications and Public Liaison at 301-496-7301.
NIGMS is one of the 27 components of NIH, the premier federal agency for biomedical research. The NIGMS mission is to support basic biomedical research that lays the foundation for advances in disease diagnosis, treatment and prevention.
Emily Carlson | EurekAlert!
Primates in peril
15.06.2018 | Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung
Flying spider - Thekla's Wondrous Journey
15.06.2018 | Technische Universität Berlin
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
15.06.2018 | Materials Sciences
15.06.2018 | Ecology, The Environment and Conservation
15.06.2018 | Power and Electrical Engineering