The Protein Structure Initiative (PSI), a national program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines.
Crystal structure of a protein with unknown function from Leishmania major, a parasite of the human immune system.
The PSI is a 10-year, approximately $600 million project funded largely by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The first half of this project—a pilot phase that started in 2000—has centered on developing new tools and processes that enable researchers to quickly, cheaply, and reliably determine the shapes of many proteins found in nature.
"One thousand protein structures is a significant milestone for the PSI, and it shows an impressive return on the investment in the technology and methods for rapid structure determination," said Jeremy M. Berg, Ph.D., director of NIGMS. "These structures are interesting in their own right and provide the basis for modeling many important proteins."
The Structural Genomics of Pathogenic Protozoa Consortium, http://www.sgpp.org/
The TB Structural Genomics Consortium, http://www.doe-mbi.ucla.edu/TB/
The pilot phase of the PSI will end in mid-2005. Centers for the second phase will be announced in July 2005.
In addition to NIGMS, the PSI currently receives funding from the National Institute of Allergy and Infectious Diseases, a component of the National Institutes of Health.
For more information about the PSI, please visit http://www.nigms.nih.gov/psi/. To schedule an interview with Jeremy M. Berg, Ph.D., or John Norvell, Ph.D., please contact the NIGMS Office of Communications and Public Liaison at 301-496-7301.
NIGMS is one of the 27 components of NIH, the premier federal agency for biomedical research. The NIGMS mission is to support basic biomedical research that lays the foundation for advances in disease diagnosis, treatment and prevention.
Emily Carlson | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy