Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD-Salk team show protein’s gene-silencing role in development of nervous system

28.01.2005


The first evidence that a group of proteins called phosphatases play a key role in the development of the nervous system, has been shown in fruit flies and mice by researchers at the University of California, San Diego (UCSD) School of Medicine, in collaboration with scientists at the Salk Institute, La Jolla, California. The phosphatases are required for maintenance of neural stem cells and for silencing expression of neuronal genes in non-nervous system tissues.



Published in the January 28, 2005 issue of the journal Science, the study found that the phosphatases, called small carboxyl-terminal domain phosphatases (SCPs) are expressed in almost all tissues of the body. In their "on" position, the phosphatases prevent neuronal genes from being expressed in areas of the body, such as the heart and liver, where they shouldn’t be. When these phosphatases are shut off in the nervous system, neuronal stem cells can develop into specialized neurons.

The researchers determined that SCPs are a component of a previously identified master gene complex called REST/NRSF, which is known to control neuronal genes. In their investigations with mice and fruit flies, the scientists found that REST/NRSF recruits SCPs only to neuronal genes. "These findings suggest a way to expand the pool of neuronal stem cells, which could lead to new therapeutic strategies for neurological disorders," said the study’s senior author, Gordon Gill, M.D., UCSD professor of medicine.


The ability of SCPs to silence genes was first shown by Gill and his post-doctoral fellow Michele Yeo, Ph.D., in an April 28, 2003 study published in the Journal of Biological Chemistry. Yeo is co-first author of the new study in Science, along with Soo-Kyung Lee, Ph.D., a post-doctoral fellow in the lab of Samuel L. Pfaff, Ph.D., associate professor, Salk Institute. Additional authors are Bora Lee, Ph.D. and Esmeralda C. Ruiz, B.S., Salk Institute.

Sue Pondrom | EurekAlert!
Further information:
http://www.ucsd.edu

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>