While large-scale genomic sequencing technologies over the past decade have given scientists databases filled with the complete genomes of hundreds of organisms, not enough is being done to interpret all that data by assigning functions to sequenced genes (annotation), according to a report released today by the American Academy of Microbiology. An Experimental Approach to Genome Annotation proposes a new initiative to help address this challenge.
"Roughly 40% of predicted genes have not been assigned even tentative functions. It is rare in science to be able to clearly delineate the boundaries of current knowledge, but that is exactly where genomics stands today," according to the report. "The annotation initiative proposed in this document will extend those boundaries and will likely lead to new applications and new progress in healthcare, biodefense, energy, the environment and agriculture."
Given the current lack of a reliable source of functional annotation data, the report recommends that a centralized genome annotation initiative be established in the United States. A key component of this initiative is the development of a centrally organized database of peer-reviewed, experimentally verified gene annotations, tied to catalogs of genes that have yet to be annotated and known biochemical functions for which a gene has yet to be found.
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
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24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy