Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

American Academy of Microbiology report proposes initiative to interpret genome data

24.01.2005


While large-scale genomic sequencing technologies over the past decade have given scientists databases filled with the complete genomes of hundreds of organisms, not enough is being done to interpret all that data by assigning functions to sequenced genes (annotation), according to a report released today by the American Academy of Microbiology. An Experimental Approach to Genome Annotation proposes a new initiative to help address this challenge.



"Roughly 40% of predicted genes have not been assigned even tentative functions. It is rare in science to be able to clearly delineate the boundaries of current knowledge, but that is exactly where genomics stands today," according to the report. "The annotation initiative proposed in this document will extend those boundaries and will likely lead to new applications and new progress in healthcare, biodefense, energy, the environment and agriculture."

Given the current lack of a reliable source of functional annotation data, the report recommends that a centralized genome annotation initiative be established in the United States. A key component of this initiative is the development of a centrally organized database of peer-reviewed, experimentally verified gene annotations, tied to catalogs of genes that have yet to be annotated and known biochemical functions for which a gene has yet to be found.


Additionally, the report cites lack of available funding as a primary reason that progress in this field has been so slow. The report recommends that the new annotation initiative provide flexible funding to support experiments that will test annotation predictions, including nontraditional funding mechanisms such as smaller awards to a greater number of laboratories and awards to support student research.

The report is based on the findings of a colloquium convened by the Academy in Washington, DC in July 2004. A group of distinguished scientists, including microbiologists, biochemists and bioinformatics specialists gathered to address the critical challenges of genome annotation and to seek ways to accelerate progress in the field of genome annotation.

"The genome sequences that exist today are a great available resource, and the potential impact they represent to us, if annotated accurately, though combined experimentation and bioinformatics, has yet to be explored," says colloquium chair Richard Roberts of New England Biolabs in Beverly, Massachusetts.

Angelo R. Bouselli | EurekAlert!
Further information:
http://www.asmusa.org
http://www.asm.org

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>