Scientists are taking the first steps to find out how a gene that is mutated in many cancer cells functions in healthy cells.
The researchers hope that learning how this gene, called Rb, operates in health cells will give them a better idea of how cancer develops and progresses. While mutations in Rb, are linked to several types of cancer including the childhood disease retinoblastoma, Rb normally keeps cell division in check. That means Rb is a tumor suppressor gene, which keeps cells from growing out of control. Scientists believe that Rb is linked to two key processes that frequently malfunction when cancer begins – proliferation (cell growth), and apoptosis (cell death). But they dont know how Rb, which is found in every cell of the body, does this. New findings reported in the December 23 issue of Nature begin to shed light on the genes role in cells.
The researchers found that in mice, a lack of Rb during embryonic development kept red blood cells from fully maturing. "While we dont think this finding has a specific link to cancer development, it is a first step to getting at the basic mechanism of how Rb works," said Gustavo Leone, a study co-author and an assistant professor with the Human Cancer Genetics Program at Ohio State University. "Knowing how Rb works in normal cells could help us to someday understand how tumor-suppressor genes function in tumor development and growth."
Gustavo Leone | EurekAlert!
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
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Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy