Scientists link gene switches to specific brain locations
Researchers at Dana-Farber Cancer Institute have compiled the first atlas showing the locations of crucial gene regulators, or switches that determine how different parts of the brain develop – and, in some cases, develop abnormally or malfunction. The scientists say the map will accelerate research on brain tumors and neurological diseases that result from mutations in these switch genes – called "transcription factors." When these genes are altered, the genes they control can go awry, causing abnormalities in the development or function of nerves and related structures.
Although the gene regulators were pinpointed using mouse brains, the map applies to the human brain as well. "This is the first systematic mapping of all of the major brain areas that shows what regulatory genes are expressed in those specific locations," said Quifu Ma, PhD, of Dana-Farbers Cancer Biology Department. He is senior author of a paper appearing in todays online issue of the journal Science, along with Charles D. Stiles, PhD, also of Dana-Farber.
Janet Haley-Dubow | EurekAlert!
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