Blocking a key molecule protects breast implants, permanent catheters, pacemakers, artificial joints, glucose sensors for diabetics, and other biomaterials from rejection and damage by the body, according to a study published this month in The American Journal of Pathology.
The more complicated the function of the implant, the more likely it is to be rendered non-functional due to damage induced by the body, said the lead author, Themis Kyriakides, assistant professor of pathology and a member of the interdepartmental program in Vascular Biology and Transplantation at Yale School of Medicine.
"Implantation of biomaterials and tissue-engineered devices into tissues cause the development of a foreign body reaction that can lead to implant failure," Kyriakides said. "The foreign body reaction has been implicated in the malfunction and failure of numerous devices and implants."
Jacqueline Weaver | EurekAlert!
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