Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of compound could enhance cancer treatments with fewer side effects

21.12.2004


The discovery of a new compound by Michigan State University researchers could lead to improved chemotherapy treatments for different types of cancers – potentially with fewer side effects.

The discovery of the compound – known as SP-4-84 – was made by an MSU team led by Jetze Tepe, an assistant professor of chemistry, and is detailed in the December issue of the journal Chemistry & Biology. The researchers believe that the compound, when used in conjunction with chemotherapy drugs such as cisplatin and camptothecin, can make the anti-cancer drugs much more effective. “This may potentially mean that one could use less than one-tenth of the current drug dosage and still get the same therapeutic results – but fewer side effects – or use the same drug dosage which is now much more effective in its treatment,” Tepe said.

Even though this new compound is in the earliest stage of development, this is potentially good news for the millions of Americans diagnosed with cancer every year. The national Centers for Disease Control and Prevention says more than a half-million Americans die of cancer every year, second only to heart disease. Here is how the newly discovered compound works: Most anti-cancer drugs work by causing cell damage, such as DNA damage, which ultimately kills the cancer cells. However, cancer cells are also prone to repair themselves and survive the damage done by drugs, which renders the drugs less effective.



Tepe and his colleagues found that when SP-4-84 was added to certain anti-cancer drugs, it inhibited the cancer cell’s ability to survive chemotherapeutic treatment. “Essentially,” he said, “it sensitizes only cancer cells to chemotherapeutics by blocking the cancer cell’s ability to survive the damage that was caused by the chemotherapeutic drugs.”

Another problem with chemotherapy drugs is that they generally don’t discriminate between cancer cells and healthy cells. The drugs basically damage all cells that are continuing to replicate. “So, if we’re able to give the patient a drug that remains as effective despite a smaller dose, this could spare the patient a lot of side effects such as severe nausea, kidney or liver damage, and other side effects typically experienced during chemotherapy,” Tepe said.

“Tests preformed with cancer cells in culture found that over a 48-hour period small amounts of SP-4-84 made camptothecin 75 times more effective that conventional treatment,” he said. “However, when we used the compound on non-cancerous cells, there was absolutely no effect. It appears right now that the compound is only selective for cancer cells.” Thus far, SP-4-84 appears to be extremely non-toxic, he said.

In their current work, Tepe and his co-workers have teamed up with MSU’s Carcinogenesis Laboratory, where the teams are evaluating the new compound in mice. "As with all new discoveries, much more work needs to be done to evaluate the potential of this compound for its ability to improve conventional therapeutic treatment,” Tepe said.

Other members of Tepe’s team include graduate students Vasudha Sharma and Satyamaheshwar Peddibhotla, and research associate Theresa Lansdell.

Tom Oswald | EurekAlert!
Further information:
http://www.msu.edu

More articles from Life Sciences:

nachricht CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

The Great Unknown: Risk-Taking Behavior in Adolescents

19.01.2017 | Studies and Analyses

Magnetic moment of a single antiproton determined with greatest precision ever

19.01.2017 | Physics and Astronomy

CRISPR meets single-cell sequencing in new screening method

19.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>