Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists discover enzyme crucial to the transportation of proteins within cells

20.12.2004


Scientists at the University of British Columbia have discovered an enzyme in mammals crucial to the transportation of proteins within cells. Published today in Neuron, this discovery opens new avenues of understanding of the mechanisms underlying neuronal function and new therapeutic approaches for neurodegenerative diseases such as Alzheimers and Huntington Disease.



The enzyme, HIP14, is a palmitoyl transferase that adds signaling molecules to proteins resulting in their transportation to specific cellular locations where they perform essential functions. This process known as palmitoylation is extremely important for the normal functioning of the nervous system where proteins are transported rapidly within nerve cells known as neurons.

Until now, scientists did not know how mammalian proteins become palmitoylated. During their study of Huntington Disease, Dr. Michael Hayden’s team at the Centre for Molecular Medicine and Therapeutics had previously identified a protein called HIP14 and recognized that it might play a role in palmitoylation. To further understand this mechanism, the Hayden team formed a partnership with Dr. Alaa El-Husseini and his team at the Brain Research Centre who are experts in the field of protein palmitoylation. Through this unique collaboration between experts in complementary fields, they discovered that HIP14 is indeed a mammalian palmitoyl transferase.


The teams also discovered that in the absence of the HIP14 enzyme, proteins were not transported to locations in the cell where they are needed. This change in protein trafficking is thought to result in severe neuronal dysfunction and may be a mechanism underlying diseases such as Alzheimers and Huntington Disease.

This research was funded by the Michael Smith Foundation for Health Research, the Canadian Institute of Health Research and the High Q Foundation.

Krista Johnston | EurekAlert!
Further information:
http://www.ubc.ca

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>