Thomas Kusch, Ph.D., a Senior Research Associate at the Stowers Institute working with Investigator Jerry Workman, Ph.D., has identified a histone-modifying complex from Drosophila melanogaster (fruit flies), which facilitates DNA double-strand repair by locally increasing DNA accessibility at sites of damage. The findings are available in the Dec. 17 issue of Science.
"DNA double strand breaks are regarded as one of the primary causes of cancer," says Kusch. "While there are natural mechanisms within an organism to detect and repair these breaks, factors involved in DNA damage repair must first bypass histones. Histones are proteins that condense DNA and protect it from mechanical and other stresses, but also make DNA rather inaccessible."
Multiprotein complexes are able to modify or mobilize histones to overcome the obstacle imposed by histones, and it has long been assumed that such complexes must act in concert with DNA repair enzymes at sites of DNA double-strand breaks. It was unclear, however, which types of histone-modifying complexes do this job, how they target sites of DNA double-strand breaks, or how they remodel histones to assist DNA repair.
Marie Jennings | EurekAlert!
Researchers uncover protein-based “cancer signature”
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A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
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