New find may be future target for medications to relieve common skin condition
Researchers at The University of Texas M. D. Anderson Cancer Center simultaneously have resolved a controversy over the cause of psoriasis and developed the first mouse model that fully mimics the human disorder. What’s more, the scientists have demonstrated they can block the signals that lead to psoriasis in their mouse model with a topical skin treatment that can prevent new outbreaks as well as treat existing psoriatic plaques. "We have developed a mouse model that exhibits all the major features of human psoriatic lesions and shown we can reverse those steps," said John DiGiovanni, Ph.D., the study’s principal investigator and director of M. D. Anderson’s Department of Carcinogenesis. "We may have found an entirely new treatment option for psoriasis."
The study, which appears in the January 2005 issue of the journal Nature Medicine, available on-line Dec. 12, shows a protein called STAT3 is a crucial initiator of psoriasis and must be present and activated for psoriasis to develop in their mouse model. Psoriasis is a chronic condition in which patches of skin become inflamed and develop itchy red, flaky scales. Areas of the body most affected include the scalp, elbows, knees, and lower back. Psoriasis affects about two percent of people worldwide, with men and women equally susceptible. Current treatment for psoriasis focuses on reducing inflammation and slowing down the rapid growth and shedding of skin cells called keratinocytes. There is no effective curative treatment for the underlying condition, according to DiGiovanni. "There has been an ongoing controversy about whether the primary defect in psoriasis is in the immune system or in the keratinocytes," says DiGiovanni. "We may have found the link - the change in keratinocytes that cooperates with the immune system cells necessary for development of human psoriasis."
Julie A. Penne | EurekAlert!
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences