New find may be future target for medications to relieve common skin condition
Researchers at The University of Texas M. D. Anderson Cancer Center simultaneously have resolved a controversy over the cause of psoriasis and developed the first mouse model that fully mimics the human disorder. What’s more, the scientists have demonstrated they can block the signals that lead to psoriasis in their mouse model with a topical skin treatment that can prevent new outbreaks as well as treat existing psoriatic plaques. "We have developed a mouse model that exhibits all the major features of human psoriatic lesions and shown we can reverse those steps," said John DiGiovanni, Ph.D., the study’s principal investigator and director of M. D. Anderson’s Department of Carcinogenesis. "We may have found an entirely new treatment option for psoriasis."
The study, which appears in the January 2005 issue of the journal Nature Medicine, available on-line Dec. 12, shows a protein called STAT3 is a crucial initiator of psoriasis and must be present and activated for psoriasis to develop in their mouse model. Psoriasis is a chronic condition in which patches of skin become inflamed and develop itchy red, flaky scales. Areas of the body most affected include the scalp, elbows, knees, and lower back. Psoriasis affects about two percent of people worldwide, with men and women equally susceptible. Current treatment for psoriasis focuses on reducing inflammation and slowing down the rapid growth and shedding of skin cells called keratinocytes. There is no effective curative treatment for the underlying condition, according to DiGiovanni. "There has been an ongoing controversy about whether the primary defect in psoriasis is in the immune system or in the keratinocytes," says DiGiovanni. "We may have found the link - the change in keratinocytes that cooperates with the immune system cells necessary for development of human psoriasis."
Julie A. Penne | EurekAlert!
Cnidarians remotely control bacteria
21.09.2017 | Christian-Albrechts-Universität zu Kiel
Immune cells may heal bleeding brain after strokes
21.09.2017 | NIH/National Institute of Neurological Disorders and Stroke
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
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21.09.2017 | Health and Medicine