Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Re-analysis of large trials shows greatest benefit of chemotherapy in ER-negative tumors

13.12.2004


Despite the common belief in the oncology community that cancer research and treatment have focused on breast tumors that are estrogen receptor (ER)-positive, a researcher from The University of Texas M. D. Anderson Cancer Center maintains that clinicians have made "enormous strides" in treating patients with tumors that are ER-negative.



In a presentation at the annual meeting of the San Antonio Breast Cancer Symposium, Donald Berry, Ph.D., a professor and chair of the Department of Biostatistics and Applied Mathematics, looked at decades of breast cancer clinical trial experience and found that "the benefit of chemotherapy advances over the last 20 years to ER-negative patients has been surprisingly dramatic."

In examining the impact of chemotherapy treatment of node-positive breast cancer in three national clinical trials, which enrolled more than 6,000 patients cumulatively, Berry found that chemotherapy has reduced the risk of death in ER-negative patients by 56 percent. "The absolute benefit has been similarly impressive, especially in comparison with the corresponding absolute benefit of chemotherapy to ER-positive patients," he says.


The studies, conducted by the Cancer and Leukemia Group B (CALGB) and the U.S. Breast Intergroup, all tested different chemotherapy regimens and doses in women whose cancer had spread to their lymph nodes, and all three showed statistically significant results. But, patients were treated "irrespective of hormone sensitivities or whether they had received tamoxifen or not," Berry says. In women who are ER-positive, tamoxifen and other SERMs (selective estrogen receptor modulators) have been shown to help prevent cancer development or recurrence.

The impact of such preventive treatments, however, was not "weighted" in these trials, he says. "People accept and act as though chemotherapy is equally beneficial independent of ER status," he says. In his analysis, Berry found that all three studies show that chemotherapy provided a statistically significant benefit for patients with ER-negative tumors, but "only a little bit of an effect for ER-positive tumors that had been treated with tamoxifen, and none of the trials showed a statistically significant benefit for higher doses of chemotherapy in ER-positive patients."

Berry says that the results will likely surprise oncologists "because everyone has assumed that ER status doesn’t matter in chemotherapy treatment, but here we show it does." That doesn’t mean, however, that patients with ER-positive tumors should not receive chemotherapy, Berry warns.

He adds that the study proves that breast cancer patients of both hormonal types are being aided by clinical advances. "The prevailing wisdom has been that science has focused on ER-positive tumors, with development of SERMs and now aromatase inhibitors, but ER-negative patients have been left in the lurch," Berry says. "Not so. This analysis demonstrates that chemotherapy use has more than doubled survival rates in women with ER-negative tumors."

Nancy Jensen | EurekAlert!
Further information:
http://www.mdanderson.org

More articles from Life Sciences:

nachricht Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
01.03.2017 | Hochschule für Angewandte Wissenschaften Hamburg

nachricht Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>