University of Rochester scientists studying a vital protein called Serum Response Factor (SRF) in mice have learned new and unexpected facts about SRFs role in early cardiovascular development, and how a defect in this gene may be an underlying cause in human miscarriages.
The research is reported in this weeks Proceedings of the National Academy of Sciences. At this point it is unclear whether subtle defects in SRF might also be linked to adult cardiovascular disease. However, the research provides a foundation for understanding how gene mutations may disrupt heart function, perhaps making some adults more susceptible to heart failure or irregular reactions to drugs.
"One reason for studying the biology of our genetic blueprint is so that we can understand how mutations in the genes encoding for proteins such as SRF may relate to human disease," says Joseph M. Miano, Ph.D., associate professor of Medicine in the Center for Cardiovascular Research at the Universitys Aab Institute of Biomedical Sciences. "Defining the full spectrum of genetic mutations is key to genetic screening and gene-based therapies."
Leslie Orr | EurekAlert!
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A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
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