Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Red wine lovers, take heart: More evidence points to the drink’s cardiac heath benefits

08.12.2004


New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis.



Diseases such as hypertension and heart failure can cause fibrosis, a hardening or stiffening of the heart tissue. This condition arises when heart cells called cardiac fibroblasts are activated. These cells secrete collagen, a protein that provides structural support for the heart.

Overactive cardiac fibroblasts cause fibrosis of the heart tissue, which then loses its ability to efficiently pump blood, said Joshua Bomser, a study co-author and an assistant professor of human nutrition at Ohio State University.


While resveratrol is already known for helping to prevent blood clots and also possibly reducing cholesterol, this is the first time that scientists have studied the compound’s direct effects on these heart cells.

The study currently appears online on the American Journal of Physiology – Heart and Circulatory Physiology website. Bomser worked with a team of researchers from the Northeastern Ohio Universities College of Medicine, led by J. Gary Meszaros.

In the current study, treating rat cardiac fibroblasts cells with resveratrol prevented the actions of a potent hormone called angiotensin II. In the case of hypertension and heart failure, angiotensin II is produced at a high level, which is the body’s way of trying to repair damage to the heart and to increase blood pressure.

But the plan usually backfires, as the hormone causes cardiac fibroblast production to go into overdrive, and, as a result, these cells produce excessive amounts of collagen – a fibrous substance found in bone, tendons, ligaments and other connective tissues. "This hyper-secretion of collagen leads to a stiffening of the heart muscle," Bomser said. "So the heart has to work harder to pump blood, which causes further damage to the myocardium."

The researchers pretreated rat cardiac fibroblasts with resveratrol prior to adding angiotensin II to the cells. Resveratrol treatment inhibited angiotensin II’s ability to cause growth and proliferation of the cardiac fibroblasts. Resveratrol also prevented these cells from turning, or differentiating, into myofibroblasts, a specialized type of fibroblast that produces large quantities of collagen. "These results suggest that resveratrol has anti-fibrotic properties in the myocardium," Bomser said.

While the researchers can’t say how much resveratrol is needed to be beneficial, previous studies suggest that drinking red wine in moderation – one or two five-ounce glasses a day – may offer protective effects. The amount of resveratrol in a bottle of red wine can vary between types of grapes and growing seasons, according to the researchers. But nearly all dark red wines – merlot, cabernet, zinfandel, shiraz and pinot noir – contain resveratrol.

This study received support from the American Heart Association – Ohio Valley Affiliate, and the Ohio Agricultural Research and Development Center.

Bomser and Meszaros conducted the study with NEOUCOM graduate students Erik Olson, Jennifer Naugle and Xiaojin Zhang.

Joshua Bomser | EurekAlert!
Further information:
http://www.ohio-state.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>