Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplanted bone marrow cells reduce liver fibrosis in mice

08.12.2004


Transplanted bone marrow cells can reduce carbon tetrachloride-induced liver fibrosis in mice and significantly improve their survival rates, according to a new study published in the December 2004 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.



Previous reports have shown that bone marrow cells can differentiate into a number of other types of cells, including liver cells, which could help patients with liver cirrhosis and chronic liver failure. To study this possibility, researchers, led by Isao Sakaida, M.D. of Japan’s Yamaguchi University, studied the effect of transplanted bone marrow cells on mice with liver fibrosis.

The researchers first caused liver fibrosis in the mice by injecting them with carbon tetrachloride (CCI4) twice a week for four weeks. They then divided the mice into two groups and treated one with green fluorescent protein-positive blood marrow cells. They treated the control group with saline. All mice continued to be treated with carbon tetrachloride. After 1, 2, 3 or 4 weeks, the researchers assessed the extent of liver fibrosis in the mice. To measure survival rates, 15 mice from the experimental group and 15 from the control group were then treated with carbon tetrachloride for an additional 25 weeks.


After five weeks of treatment with carbon tetrachloride, the researchers detected liver fibrosis in the mice. Just one week after blood marrow cell transplantation, they found evidence of those cells in the liver, with more appearing as the weeks passed. "Surprisingly," the researchers report, "four weeks later, the blood marrow cell-transplanted liver clearly showed reduction of liver fibrosis compared with the liver treated with CCI4 alone at 8 weeks."

Furthermore, the mice that received blood marrow cell transplants along with continuing carbon tetrachloride treatments showed a gradually increased serum albumin level and had significantly improved survival rates compared with mice that only received carbon tetrachloride treatments.

The transplanted blood marrow cells degraded collagen fibers and reduced liver fibrosis, exhibiting strong expression of matrix metalloproteinases (MMPs), especially MMP-9. "The reason for the strong expression of MMP-9 is still unknown," report the authors, but report that it was somehow related to the migration of the blood marrow cells to the inflammatory liver and to those cells’ degradation of the liver fibrosis.

"The present study clearly indicates that this subpopulation of blood marrow cells is responsible for the resolution of liver fibrosis induced by CCI4 treatment," the authors conclude, and "introduces a new concept for the treatment of liver fibrosis."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/hepatology
http://www.wiley.com

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>