Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplanted bone marrow cells reduce liver fibrosis in mice

08.12.2004


Transplanted bone marrow cells can reduce carbon tetrachloride-induced liver fibrosis in mice and significantly improve their survival rates, according to a new study published in the December 2004 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD). Published by John Wiley & Sons, Inc., Hepatology is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.



Previous reports have shown that bone marrow cells can differentiate into a number of other types of cells, including liver cells, which could help patients with liver cirrhosis and chronic liver failure. To study this possibility, researchers, led by Isao Sakaida, M.D. of Japan’s Yamaguchi University, studied the effect of transplanted bone marrow cells on mice with liver fibrosis.

The researchers first caused liver fibrosis in the mice by injecting them with carbon tetrachloride (CCI4) twice a week for four weeks. They then divided the mice into two groups and treated one with green fluorescent protein-positive blood marrow cells. They treated the control group with saline. All mice continued to be treated with carbon tetrachloride. After 1, 2, 3 or 4 weeks, the researchers assessed the extent of liver fibrosis in the mice. To measure survival rates, 15 mice from the experimental group and 15 from the control group were then treated with carbon tetrachloride for an additional 25 weeks.


After five weeks of treatment with carbon tetrachloride, the researchers detected liver fibrosis in the mice. Just one week after blood marrow cell transplantation, they found evidence of those cells in the liver, with more appearing as the weeks passed. "Surprisingly," the researchers report, "four weeks later, the blood marrow cell-transplanted liver clearly showed reduction of liver fibrosis compared with the liver treated with CCI4 alone at 8 weeks."

Furthermore, the mice that received blood marrow cell transplants along with continuing carbon tetrachloride treatments showed a gradually increased serum albumin level and had significantly improved survival rates compared with mice that only received carbon tetrachloride treatments.

The transplanted blood marrow cells degraded collagen fibers and reduced liver fibrosis, exhibiting strong expression of matrix metalloproteinases (MMPs), especially MMP-9. "The reason for the strong expression of MMP-9 is still unknown," report the authors, but report that it was somehow related to the migration of the blood marrow cells to the inflammatory liver and to those cells’ degradation of the liver fibrosis.

"The present study clearly indicates that this subpopulation of blood marrow cells is responsible for the resolution of liver fibrosis induced by CCI4 treatment," the authors conclude, and "introduces a new concept for the treatment of liver fibrosis."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/hepatology
http://www.wiley.com

More articles from Life Sciences:

nachricht Bacteria as pacemaker for the intestine
22.11.2017 | Christian-Albrechts-Universität zu Kiel

nachricht Researchers identify how bacterium survives in oxygen-poor environments
22.11.2017 | Columbia University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Corporate coworking as a driver of innovation

22.11.2017 | Business and Finance

PPPL scientists deliver new high-resolution diagnostic to national laser facility

22.11.2017 | Physics and Astronomy

Quantum optics allows us to abandon expensive lasers in spectroscopy

22.11.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>