The critical decoding structure produced when modified nucleosides enable tRNA to decode by wobble recognition. Only the decoding region of a 50,000+ atom structure of the ribosome (small subunit) is shown. The modified nucleoside platform (orange) that stabilizes the codon-anticodon interaction, and the modified nucleoside that wobbles (green) are shown. The structure was determined at the atomic resolution of -3 angstroms (3 X 10 –10 meters).
A recent finding by a North Carolina State University biochemist advances the fundamental biology of how genetic information, encoded in DNA, is decoded for the production of proteins.
Dr. Paul F. Agris, professor of biochemistry at NC State, and academic colleagues from England and Poland show concrete evidence in favor of the 1966 “Wobble Hypothesis” offered by Francis Crick, the co-founder of the DNA molecule and its double-helix structure, and Agris’ own “Modified Wobble Hypothesis” posed in 1991. The scientists used x-ray crystallography of the cell’s protein-manufacturing unit, the ribosome, to provide a visual snapshot of the decoding process.
The research is published in the December 2004 edition of Nature Structural and Molecular Biology.
Mick Kulikowski | EurekAlert!
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