DR5 gene silencing image
Molecular beacons, gene silencing, and reporter genes studied to better predict response to chemotherapy
Researchers at the Abramson Cancer Center of the University of Pennsylvania are applying a host of imaging techniques to develop better ways to look noninvasively at the molecular characteristics of tumors. The experiments, now in human cell cultures and mouse models, are aimed at better forecasting early response to chemotherapy so that treatment choices can be adjusted.
"Right now in cancer therapy, with the exception of relatively uncommon examples of cancers for which we have tumor markers, we don’t have reliable ways of predicting who is going to respond early on to chemotherapy," says Wafik El-Deiry, MD, PhD, Associate Professor, Departments of Medicine, Genetics, and Pharmacology. "Currently cancer patients get their chemo and you can’t tell if they’re responding for several weeks. We need to have tests that will tell us if patients are going to respond to the chemo or the radiation soon after it’s first given, and whether these responses are going to last."
: Karen Kreeger | EurekAlert!
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