University of Pittsburgh study focuses on genes regulating the inflammatory response
Specific variants in genes that encode proteins regulating inflammation may hold a key to explaining a host of disease processes known to cause increased risk of illness and death among African Americans, according to a study from the University of Pittsburghs Graduate School of Public Health (GSPH). The study, "Differential Distribution of Allelic Variants in Cytokine Genes Among African Americans and White Americans," appears in the Dec. 1 issue of the American Journal of Epidemiology.
"We found that African Americans were significantly more likely to carry genetic variants known to stimulate the inflammatory response," said Roberta B. Ness, M.D., M.P.H., professor and chair of the department of epidemiology at GSPH and the studys primary author. "At the same time, genotypes known to dampen the release of anti-inflammatory proteins were more common among African Americans. This is kind of a double whammy."
Michele D. Baum | EurekAlert!
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