Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Patients’ own stem cells used to cure incontinence

30.11.2004


Austrian researchers are successfully treating incontinent women with the patient’s own muscle-derived stem cells. The findings of the first clinical study of its kind were presented today at the annual meeting of the Radiological Society of North America (RSNA).

"Urinary incontinence is a major problem for women, and for an increasing number of men," said Ferdinand Frauscher, M.D., associate professor of radiology at the Medical University of Innsbruck and the head of uroradiology at University Hospital. "We believe we have developed a long-lasting and effective treatment that is especially promising because it is generated from the patient’s own body."

The stem cells are removed from a patient’s arm, cultured in a lab for six weeks, and then injected into the wall of the urethra and into the sphincter muscle. The result is increased muscle mass and contractility of the sphincter and a thicker urethra. Many patients have no urinary leakage within 24 hours after the 15- to 20-minute outpatient procedure.



Stress incontinence affects nearly 15 million people – primarily women – around the world. It occurs when the urethra narrows or becomes otherwise abnormal, or when the sphincter muscles that help open and close the urethra become weak or diminished, causing urine leakage when an individual exercises, coughs, sneezes, laughs or lifts heavy objects.

Twenty females, ages 36 to 84, who were experiencing minor to severe stress incontinence participated in the research. Muscle-derived stem cells were removed from each patient’s arm and cultured, or grown, using a patented technique that yielded 50 million new muscle cells (myoblasts) and 50 million connective tissue cells (fibroblasts) after six weeks. When implanted into the patient under general or local anesthetia, the new stem cells began to replicate the existing cells nearby. One year after the procedure, 18 of the study’s 20 patients remain continent.

"These are very intelligent cells," Dr. Frauscher said. "Not only do they stay where they are injected, but also they quickly form new muscle tissue and when the muscle mass reaches the appropriate size, the cell growth ceases automatically."

Since the stem cells must be in contact with urethra and sphincter tissue for the procedure to work, a major factor in the success of this treatment was the development of transurethral three-dimensional ultrasound. "With real-time ultrasound, we are able to see exactly where the new cells must be placed," Dr. Frauscher said.

Stem cells are unspecialized cells capable of renewing themselves through cell division. Scientists believe that adult stem cells are located in small numbers throughout the tissues of the human body, where they quietly reside until activated by disease or injury and begin dividing. In addition to repairing body tissue, stem cells can be induced to become cells for specialized functions of the body.

Dr. Frauscher said the cost of the stem cell procedure was comparable to two popular treatments for incontinence: the long-term purchase and use of absorbents, such as adult diapers, and collagen injections, which show improvement during the first six months but often result in symptoms returning after a year. Dr. Frauscher also said the stem cell treatment appears to be more successful with women at this time. For men, incontinence is often caused by prostate surgery, which may result in scar tissue formation, where the stem cells do not grow very well. In men without scar tissue stem cell therapy seems to work as well as in women, Dr. Frauscher said.
Co-authors of the Austrian study are Andrea Klauser, M.D., Dieter Zur Nedden, M.D., Leo Pallwein, M.D., Rainer Marksteiner, Ph.D., Hannes Strasser, M.D., and Georg Bartsch, M.D.

Maureen Morley | EurekAlert!
Further information:
http://www.rsna.org

More articles from Life Sciences:

nachricht Organ Crosstalk: Fatty Liver Can Cause Damage to Other Organs
18.08.2017 | Deutsches Zentrum für Diabetesforschung

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>