Findings may aid diagnosis and indicate new treatment target for many cancers
A new study from Columbia University Medical Center finds that stomach (gastric) cancer originates from bone marrow derived stem cells (BMDC), rather than from stomach stem cells, as previously thought. The study, "Gastric Cancer Originating from Bone Marrow-Derived Cells" is published in the current issue of Science. "This was an unexpected finding, which may lead to a re-evaluation of current assumptions about how all cancers originate," said Timothy C. Wang, M.D., chief, Division of Digestive and Liver Diseases and Dorothy L. and Daniel H. Silberberg Professor of Medicine at Columbia University College of Physicians and Surgeons and senior author of the study. "The implications of this study may lead to new methods of diagnosis and treatment of many cancers – particularly those that have been linked to chronic inflammation such as stomach, esophagus, lung, pancreas, liver, etc."
A common assumption among cancer specialists is that most cancers originate from tissue stem cells – for example, the gastric stem cells contained in the lining of the stomach. However, the researchers suspected BMDC may contribute to the development or progression of cancer because they are frequently recruited to sites of tissue injury and inflammation, e.g., a typical site for cancer development.
Elizabeth Streich | EurekAlert!
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