Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research shows stomach (gastric) cancer originates from bone marrow derived stem cells

26.11.2004


Findings may aid diagnosis and indicate new treatment target for many cancers



A new study from Columbia University Medical Center finds that stomach (gastric) cancer originates from bone marrow derived stem cells (BMDC), rather than from stomach stem cells, as previously thought. The study, "Gastric Cancer Originating from Bone Marrow-Derived Cells" is published in the current issue of Science. "This was an unexpected finding, which may lead to a re-evaluation of current assumptions about how all cancers originate," said Timothy C. Wang, M.D., chief, Division of Digestive and Liver Diseases and Dorothy L. and Daniel H. Silberberg Professor of Medicine at Columbia University College of Physicians and Surgeons and senior author of the study. "The implications of this study may lead to new methods of diagnosis and treatment of many cancers – particularly those that have been linked to chronic inflammation such as stomach, esophagus, lung, pancreas, liver, etc."

A common assumption among cancer specialists is that most cancers originate from tissue stem cells – for example, the gastric stem cells contained in the lining of the stomach. However, the researchers suspected BMDC may contribute to the development or progression of cancer because they are frequently recruited to sites of tissue injury and inflammation, e.g., a typical site for cancer development.


Results found that chronic infection with Helicobacter pylori (known as H. pylori), a common type of bacteria known to cause inflammation and ulcers in the stomach and a known carcinogen, leads to the death of most normal stomach cells. As a result, BMDCs arrive in numbers in an attempt to repair the site. These BMDCs, which are somewhat prone to undergo transformation, progress over time into stomach cancer cells. The research was conducted in mouse models.

"With this clearer understanding of the connection between bone marrow derived stem cells and stomach cancer, I plan to establish screening models for people at high risk of cancer and work to translate the findings into new treatments that specifically target these cells, at the Herbert Irving Comprehensive Cancer Center of Columbia University Medical Center," said Dr. Wang.

About Stomach (Gastric) Cancer

Stomach cancer is a grave problem in much of the world – especially Asia, Eastern Europe and parts of Latin America – where it’s second only to lung cancer as a cause of cancer deaths.

In the United States and Western Europe, the incidence of stomach cancer has declined dramatically over the past 50 years; however, it remains a very deadly disease. While the survival rate is much more favorable when diagnosed early, unfortunately it is often diagnosed at advanced stages, often because its symptoms – which include bloating, diarrhea, nausea and fatigue – can easily confused with other common conditions. The five-year survival rate for stomach cancer in the United States is approximately 22 percent.

Elizabeth Streich | EurekAlert!
Further information:
http://www.columbia.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>