Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Peripheral timekeeping: Mammalian cells outside the brain have their own circadian clocks

24.11.2004


Researchers have discovered that individual fibroblast cells contain independent, self-sustaining circadian (ca. 24 hr) clocks. Circadian clocks are important for synchronizing many physiological and behavioral processes to the day/night cycle.

For decades it has been known that a tiny cluster of brain cells known as the suprachiasmatic nucleus (SCN) is required for expression of circadian rhythms in mammals. When clock genes were identified in the late ’90s, they were found to be expressed rhythmically not only in SCN but also in many other tissues. Some of these studies used the firefly luciferase gene, introduced into cells with regulatory elements from a clock gene, so that cell cultures emitted light with a circadian rhythm. However, peripheral tissue rhythms tended diminish after a few cycles in culture, suggesting that they might depend on the central nervous system’s SCN to drive them.

In the new work, performed by researchers at The Scripps Research Institute and Northwestern University, Dr. David Welsh and colleagues used bioluminescence imaging to monitor circadian rhythms of clock gene expression from individual rat or mouse fibroblasts. Robust rhythms of single cells persisted without diminishing for at least 1–2 weeks in culture. Cells were partially synchronized by medium change at the start of an experiment, but because of different circadian periods drifted out of phase after several days, leading the ensemble rhythm to diminish. Thus, even cells outside the brain contain bona fide circadian clocks.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>