Johns Hopkins researchers say there is growing evidence that stem cells gone awry in their efforts to repair tissue damage could help explain why long-term irritation, such as from alcohol or heartburn, can create a breeding ground for certain cancers.
At the heart of their argument, outlined in the Nov. 18 issue of Nature, are two key chemical signals, called Hedgehog and Wnt ("wint"), that are active in the stem cells that repair damaged tissue. Recently and unexpectedly, the signals also have been found in certain hard to treat cancers, supporting an old idea that some cancers may start from normal stem cells that have somehow gone bad.
Over the last 10 years, researchers have found examples of these so-called cancer stem cells -- the cells within a tumor that are capable of regrowing the tumor -- in certain malignancies of the blood, breast and brain. In most cases, however, its not clear whether these cancer stem cells came from the tissues normal, primitive stem cells or from the tissues mature cells.
Joanna Downer | EurekAlert!
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The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
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