Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth. The method enabled the discovery of a new cancer gene, which, when damaged, may promote prostate cancer. Prostate cancer is the most diagnosed form of cancer in men; it is also becoming increasingly common. Thus, this finding may have great significance for the development of new forms of therapy.
The researchers developed a method for the effective screening and identification of tumor growth-suppressing genes and their mutations. With the new technique, it is possible to identify potential tumor-suppressor genes from among the approximately 25,000 human genes and accelerate research significantly. The new microarray-based method allows the efficient screening of thousands of genes in a single laboratory experiment.
The effectiveness of the method is due to the combination of two screening methods: the NMD (nonsense-mediated mRNA decay) microarray technique is used to screen for mutated genes, while the CGH (comparative genomic hybridization) microarray technique is used to screen for DNA copy number losses from the same sample. By combining these findings researchers can efficiently pinpoint those genes whose function has failed in cancer cells
Maija Wolf, PhD | alfa
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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