Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

International research team identifies gene that promotes prostate cancer

24.11.2004


Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth. The method enabled the discovery of a new cancer gene, which, when damaged, may promote prostate cancer. Prostate cancer is the most diagnosed form of cancer in men; it is also becoming increasingly common. Thus, this finding may have great significance for the development of new forms of therapy.



The researchers developed a method for the effective screening and identification of tumor growth-suppressing genes and their mutations. With the new technique, it is possible to identify potential tumor-suppressor genes from among the approximately 25,000 human genes and accelerate research significantly. The new microarray-based method allows the efficient screening of thousands of genes in a single laboratory experiment.

The effectiveness of the method is due to the combination of two screening methods: the NMD (nonsense-mediated mRNA decay) microarray technique is used to screen for mutated genes, while the CGH (comparative genomic hybridization) microarray technique is used to screen for DNA copy number losses from the same sample. By combining these findings researchers can efficiently pinpoint those genes whose function has failed in cancer cells


Using this novel approach the researchers were able to find errors in the EPHB2 gene. The gene encodes a cell membrane receptor, which has a role in the intracellular communication, and is required for cell differentiation, cell mobility and maintenance of correct tissue structure. A defect in the EPHB2 gene function may thus cause tissue dysorganization and promote the proliferation and metastatis of cancer cells. This finding helps to provide a better understanding of the molecular mechanisms involved in the development and progression of cancer, which is an essential step in the development of novel anti-cancer therapies.

Researchers found mutations in EPHB2 gene in 8% of prostate cancer patients, particularly in the metastatic tumors. The discovery is hoped to facilitate the development of novel therapeutics for prostate cancer. The researches aim to develop the novel NMD-CGH microarray method further and apply it for new tumor-suppressor gene discovery approaches in prostate cancer and other cancer types.

Launched three years ago at the National Institutes of Health (NIH) in the United States, the research was continued in Finland at VTT in the Medical Biotechnology Department, in collaboration with a research team at the Translational Genomics Research institute in the US.

Prostate cancer is the most common cancer in men, the incidence of which has shown an increasing trend over the past few years. The origins of prostate cancer remain largely unknown, however, researchers believe that genetic errors occurring in prostate cells during the aging process have a significant impact. The loss of function of the tumor-suppressor genes plays a major role in the development of cancer. So far approximately twenty such genes have been identified in the human genome. Their normal function ensures the correct growth of cells and prevents the proliferation of cancer cells in the body.

Maija Wolf, PhD | alfa
Further information:
http://www.vtt.fi

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>