Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCI researchers use human embryonic stem cells to aid spinal cord injury repair

22.11.2004


Discovery shows stem cell-derived ‘insulation’ cells growing and functioning in a living system



For the first time, researchers have used human embryonic stem cells to create new insulating tissue for nerve fibers in a live animal model – a finding that has potentially important implications for treatment of spinal cord injury and multiple sclerosis.

Researchers at the UC Irvine Reeve-Irvine Research Center used human embryonic stem cells to create cells called oligodendrocytes, which are the building blocks of the myelin tissue that wraps around and insulates nerve fibers. This tissue is critical for maintenance of proper nerve signaling in the central nervous system, and, when it is stripped away through injury or disease, sensory and motor deficiencies and, in some cases, paralysis result.


In this study, neurologist Hans Keirstead and colleagues at UCI and the Geron Corporation devised a novel technique that allows human embryonic stem cells to differentiate into high-purity, early-stage oligodendrocyte cells. The researchers then injected these cells into the spinal cords of mice genetically engineered to have no myelin tissue.

After transplantation into mice, the early-stage cells formed into full-grown oligodendrocyte cells and migrated to appropriate neuronal sites within the spinal cord. More importantly, the researchers discovered the oligodendrocyte cells forming patches of myelin’s basic protein, and they observed compact myelin tissue wrapping around neurons in the spinal cord. These studies demonstrated that the oligodendrocytes derived from human embryonic stem cells can function in a living system. Results of this study are published online in the peer-reviewed journal Glia. “These results are extremely exciting and show great promise,” Keirstead said. “What we plan to do next is see how these cells improve sensory and motor function, and hopefully it will lead to further tests with people who suffer from these debilitating illnesses and injuries.”

Gabriel I. Nistor and Minodora O. Totoiu from UCI collaborated with Nadia Haque and Melissa K. Carpenter of the Geron Corporation on the study, which was supported by Geron, UC Discovery, Research for Cure and the Reeve-Irvine Research Center. Geron provided the human embryonic stem cells used in this study. In previous studies, Keirstead and colleagues have identified how the body’s immune system attacks and destroys myelin tissue during spinal cord injury or disease states. They’ve also shown that, when treated with antibodies to block immune system response, myelin is capable of regenerating, which ultimately restores sensory and motor activity.

The Reeve-Irvine Research Center was established to study how injuries and diseases traumatize the spinal cord and result in paralysis or other loss of neurologic function, with the goal of finding cures. It also facilitates the coordination and cooperation of scientists around the world seeking cures for paraplegia, quadriplegia and other diseases impacting neurological function. Named in honor of Christopher Reeve, the center is part of the UCI College of Medicine.

Tom Vasich | EurekAlert!
Further information:
http://www.uci.edu

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>