Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


UCI researchers use human embryonic stem cells to aid spinal cord injury repair


Discovery shows stem cell-derived ‘insulation’ cells growing and functioning in a living system

For the first time, researchers have used human embryonic stem cells to create new insulating tissue for nerve fibers in a live animal model – a finding that has potentially important implications for treatment of spinal cord injury and multiple sclerosis.

Researchers at the UC Irvine Reeve-Irvine Research Center used human embryonic stem cells to create cells called oligodendrocytes, which are the building blocks of the myelin tissue that wraps around and insulates nerve fibers. This tissue is critical for maintenance of proper nerve signaling in the central nervous system, and, when it is stripped away through injury or disease, sensory and motor deficiencies and, in some cases, paralysis result.

In this study, neurologist Hans Keirstead and colleagues at UCI and the Geron Corporation devised a novel technique that allows human embryonic stem cells to differentiate into high-purity, early-stage oligodendrocyte cells. The researchers then injected these cells into the spinal cords of mice genetically engineered to have no myelin tissue.

After transplantation into mice, the early-stage cells formed into full-grown oligodendrocyte cells and migrated to appropriate neuronal sites within the spinal cord. More importantly, the researchers discovered the oligodendrocyte cells forming patches of myelin’s basic protein, and they observed compact myelin tissue wrapping around neurons in the spinal cord. These studies demonstrated that the oligodendrocytes derived from human embryonic stem cells can function in a living system. Results of this study are published online in the peer-reviewed journal Glia. “These results are extremely exciting and show great promise,” Keirstead said. “What we plan to do next is see how these cells improve sensory and motor function, and hopefully it will lead to further tests with people who suffer from these debilitating illnesses and injuries.”

Gabriel I. Nistor and Minodora O. Totoiu from UCI collaborated with Nadia Haque and Melissa K. Carpenter of the Geron Corporation on the study, which was supported by Geron, UC Discovery, Research for Cure and the Reeve-Irvine Research Center. Geron provided the human embryonic stem cells used in this study. In previous studies, Keirstead and colleagues have identified how the body’s immune system attacks and destroys myelin tissue during spinal cord injury or disease states. They’ve also shown that, when treated with antibodies to block immune system response, myelin is capable of regenerating, which ultimately restores sensory and motor activity.

The Reeve-Irvine Research Center was established to study how injuries and diseases traumatize the spinal cord and result in paralysis or other loss of neurologic function, with the goal of finding cures. It also facilitates the coordination and cooperation of scientists around the world seeking cures for paraplegia, quadriplegia and other diseases impacting neurological function. Named in honor of Christopher Reeve, the center is part of the UCI College of Medicine.

Tom Vasich | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife

nachricht Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

Advanced analysis of brain structure shape may track progression to Alzheimer's disease

26.10.2016 | Health and Medicine

3-D-printed structures shrink when heated

26.10.2016 | Materials Sciences

More VideoLinks >>>