The identification of a gene expression profile using microarray technology may help clinicians better determine the prognosis of patients with advanced stage ovarian cancer and may eventually help provide targeted therapies for this hard-to-treat disease, according to a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC).
The findings, described in an advance on-line publication of the December issue of the Journal of Clinical Oncology, represent the first time that this type of genetic test has proven useful as a prognostic tool for ovarian cancer, which accounts for approximately 26,000 new cases and 16,000 deaths in the United States each year. "Ovarian cancer is widely recognized as being extremely difficult to treat," explains Stephen A. Cannistra, M.D., Director of Gynecologic Medical Oncology at BIDMC and Associate Professor of Medicine at Harvard Medical School. "Because symptoms often do not appear until the disease has already spread to the upper abdomen, this malignancy is usually not diagnosed until it has reached an advanced stage." At that point, he adds, doctors typically use clinical data – such as the amount of residual disease remaining following surgery – to assess a patients prognosis and determine their course of therapy, a method that Cannistra notes is admittedly imperfect.
Knowing that the behavior of cancers is partly dependent upon which genes are turned on and off in tumor cells, researchers have long suspected that a better understanding of the genetic profile of the tumors of individual patients could help in making a more accurate prognosis. "With the advent of microarray analysis -- in which genes expressed by the cancer cells are labeled with a probe and then applied to a glass slide that contains embedded sequences of thousands of known human genes – this type of genetic information has become much more accessible," explains Cannistra. "[Through this process] genes that are present in the tumor cell bind to their counterpart sequences on the glass slide, thereby permitting their identification with the aid of computer analysis."
Bonnie Prescott | EurekAlert!
Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital
New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy