In a developing embryo, the growth of nerves cannot outpace the establishment of life-giving blood vessels. Now, researchers have found that a protein intimately involved in blood vessel patterning actually belongs to a family of proteins known to guide neural development.
The researchers said the studies provide more evidence of communication between developing nerves and blood vessels. Understanding how those networks talk to each other could help researchers devise methods to prevent blood vessel growth in tumors selectively - an approach to cancer treatment known as anti-angiogenesis. The research team, which included Howard Hughes Medical Institute investigators David D. Ginty and Thomas M. Jessell, published its findings November 18, 2004, in Science Express, the early online version of the journal Science. Co-first authors of the paper were Chenghua Gu in Gintys laboratory at The Johns Hopkins University School of Medicine, and Yutaka Yoshida in Jessells laboratory at Columbia University.
In their experiments, the researchers explored the roles of two proteins involved in vascular development. One of the molecules, Semaphorin 3E (Sema3E), is a member of a family of protein signals that guides the growth of nerve cells. The other protein, plexin-D1, is a receptor protein that nestles in the membranes of growing cells and responds to external signaling proteins. Ginty said that before the current study, plexin-D1 was known to be important for vascular development, but the specific signal to which it responded was a mystery. The molecule was also considered an important receptor in nerve cell development, and for that reason Jessells laboratory was actively investigating plexin-D1.
Jim Keeley | EurekAlert!
Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY
Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center
A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Physics and Astronomy
24.01.2017 | Life Sciences
24.01.2017 | Health and Medicine