Discovery may one day lead to new ways to treat degenerative diseases
Scientists at Stanford University and Joslin Diabetes Center are providing new insights into how muscle cells regenerate -- leading to powerful tools to help scientists better understand diseases such as muscular dystrophy. Skeletal muscle contains a complex array of cell types. Among its principal components are multi-nucleated muscle fibers and muscle satellite cells -- cells located in close association with muscle fibers and containing precursors capable of giving rise to new muscle fibers.
"Our studies show that only the satellite cells, located near muscle fibers, can give rise to new muscle cells. Contrary to previous studies, precursor cells from bone marrow or other blood-forming tissues did not change their destiny to become muscle cells," said Amy J. Wagers, Ph.D., Investigator in the Developmental and Stem Cell Biology Research Section at Joslin Diabetes Center and Assistant Professor of Pathology at Harvard Medical School, the principal investigator of a study published in the Nov. 12 edition of Cell. The research, which originated in the laboratory of Irving L. Weissman, M.D., at Stanford University, now continues at Joslin Diabetes Center in Boston. Over the past few years, several research groups have reported that stem cells found in the bone marrow could repair damaged muscle cells. This had raised hopes that the well-characterized blood-forming stem cells could be used therapeutically to treat muscular diseases. Dr. Wagers work disputes these past results, showing that bone marrow stem cells do move to the muscle but dont regularly participate in repairing muscle damage.
Marjorie Dwyer | EurekAlert!
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The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
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