Discovery may one day lead to new ways to treat degenerative diseases
Scientists at Stanford University and Joslin Diabetes Center are providing new insights into how muscle cells regenerate -- leading to powerful tools to help scientists better understand diseases such as muscular dystrophy. Skeletal muscle contains a complex array of cell types. Among its principal components are multi-nucleated muscle fibers and muscle satellite cells -- cells located in close association with muscle fibers and containing precursors capable of giving rise to new muscle fibers.
"Our studies show that only the satellite cells, located near muscle fibers, can give rise to new muscle cells. Contrary to previous studies, precursor cells from bone marrow or other blood-forming tissues did not change their destiny to become muscle cells," said Amy J. Wagers, Ph.D., Investigator in the Developmental and Stem Cell Biology Research Section at Joslin Diabetes Center and Assistant Professor of Pathology at Harvard Medical School, the principal investigator of a study published in the Nov. 12 edition of Cell. The research, which originated in the laboratory of Irving L. Weissman, M.D., at Stanford University, now continues at Joslin Diabetes Center in Boston. Over the past few years, several research groups have reported that stem cells found in the bone marrow could repair damaged muscle cells. This had raised hopes that the well-characterized blood-forming stem cells could be used therapeutically to treat muscular diseases. Dr. Wagers work disputes these past results, showing that bone marrow stem cells do move to the muscle but dont regularly participate in repairing muscle damage.
Marjorie Dwyer | EurekAlert!
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
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21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy