’Cytological profiling’ could streamline early phases of drug discovery
Bringing an unprecedented level of automation to microscopy, scientists at Harvard University have developed a powerful new method of visualizing drugs’ multifaceted impact on cells. The technique, which could eventually become a standard tool for drug discovery, is described this week in the journal Science.
Steven J. Altschuler and Lani F. Wu, mathematicians skilled in developing models to find meaningful patterns among mountains of data, worked with Timothy J. Mitchison of Harvard Medical School to automate microscopic imaging of drug-treated cells and recast the resulting scans in a computer-friendly format. The result: a method dubbed "cytological profiling" that trains computers to recognize cell status and health from cellular images, virtually automating microscopic scanning for various types of abnormalities.
Steve Bradt | EurekAlert!
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On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
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