Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU team develops enhanced algorithm for detecting changes in cancer genomes

09.11.2004


Researchers at New York University’s Courant Institute of Mathematical Sciences have developed a new algorithm that can lead to more accurate detection of cancer genes than previous versions. The algorithm, published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), can also be applied to the multiple biomedical technologies (e.g., different kinds of micro-arrays) used to analyze cancer patients’ genomes.



Headed by NYU Professor Bud Mishra, the research team developed the algorithm to detect the genetic differences between normal cells and cancer cells. Its application reveals several excess as well as missing copies of DNA segments associated with various forms of cancer and ultimately, points to locations of both oncogenes and tumor suppressor genes. In addition, the algorithm can be used to account for the varied genomes present across human population.

An earlier version of the algorithm as well as several other competing algorithms were capable of dealing with only cancer data or only polymorphism data and were unable to separate variations in cancerous and non-cancerous genes in a single framework.


Mishra’s team, which forms NYU’s Bioinfomatics Group, has previously examined new genomic technology for mapping and sequencing with single molecules, models of genome evolution, and computational and systems biology models of biological processes like apoptosis, cell divisions, and others involved in cancer.

Two senior research scientists from the Bioinformatics Group, Raoul-Sam Daruwala and Archisman Rudra, collaborated with Mishra to devise the algorithm and create its software implementation. Daruwala, Rudra, and Mishra were joined in the study by colleagues from Cold Spring Harbor Laboratory and NYU School of Medicine.

The algorithm runs through Valis, a software environment developed by Mishra and Courant’s Salvatore Paxia in 2001, with the help of a New York State Office of Science, Technology and Academic Research (NYSTAR) grant. The software will be made available on-line in mid-December. This research was also funded by the Army’s Prostate Cancer Research Program (PCRP).

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

More articles from Life Sciences:

nachricht Closing the carbon loop
08.12.2016 | University of Pittsburgh

nachricht Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>