Immune responses to prevent or delay the spread of melanoma, a deadly form of skin cancer, are more likely to prolong survival in patients if their immune cells carry a special kind of marker on the surface, according to a team of researchers at the University of Virginia Health System. The finding is published in the November 1 issue of the journal Cancer Research, found on the web at http://cancerres.aacrjournals.org/
The researchers correlated the presence or absence of the protein with survival in 52 U.Va. patients with advanced metastatic melanoma who were enrolled in experimental clinical trials over the last decade. They found that survival increased by fifty percent in patients whose T lymphocytes (the immune cells that kill tumors) carried a particular protein, or chemokine receptor, called CXCR3.
Increased survival was seen in patients with Stage III metastatic melanoma, but no increased survival was noticed in patients with Stage IV, stressing the importance of early detection and treatment for melanoma. "As immunologists continue to target the spread of cancer, this research gives scientists new clues to help develop vaccines that both ’turn-on’ cancer-killing immune cells, as well as instruct the cells on how to find tumors. Together, that will improve the efficacy of vaccines against cancer in the future," said the study’s principal investigator David W. Mullins, PhD, assistant professor of microbiology and a researcher in the Human Immune Therapy Center (HITC) at the U.Va. Health System.
Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg
Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Life Sciences
19.10.2017 | Interdisciplinary Research
19.10.2017 | Earth Sciences