Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Link between immune protein and longer survival in melanoma patients identified

05.11.2004


Immune responses to prevent or delay the spread of melanoma, a deadly form of skin cancer, are more likely to prolong survival in patients if their immune cells carry a special kind of marker on the surface, according to a team of researchers at the University of Virginia Health System. The finding is published in the November 1 issue of the journal Cancer Research, found on the web at http://cancerres.aacrjournals.org/

The researchers correlated the presence or absence of the protein with survival in 52 U.Va. patients with advanced metastatic melanoma who were enrolled in experimental clinical trials over the last decade. They found that survival increased by fifty percent in patients whose T lymphocytes (the immune cells that kill tumors) carried a particular protein, or chemokine receptor, called CXCR3.

Increased survival was seen in patients with Stage III metastatic melanoma, but no increased survival was noticed in patients with Stage IV, stressing the importance of early detection and treatment for melanoma. "As immunologists continue to target the spread of cancer, this research gives scientists new clues to help develop vaccines that both ’turn-on’ cancer-killing immune cells, as well as instruct the cells on how to find tumors. Together, that will improve the efficacy of vaccines against cancer in the future," said the study’s principal investigator David W. Mullins, PhD, assistant professor of microbiology and a researcher in the Human Immune Therapy Center (HITC) at the U.Va. Health System.



The idea behind this type of vaccine is to activate an immune response within the body against melanoma. In the past, Mullins explained, physicians have delivered vaccines that can get lost in the circulatory system. But, researchers can now target vaccines to certain lymph nodes in the body that they know will generate T cells with the appropriate chemokine receptor like CXCR3- a ’homing’ feature that allows these killer cells to find and eradicate tumors. "This data may indicate that early melanoma vaccination is essential, and that vaccines inducing specific T cells with tumor-homing ability can make a significant difference in survival," said study co-author Irene Mullins, an instructor in the Department of Health Evaluation Sciences at U.Va. "With lung disease for example, where surgery may not be an option, vaccines offer a treatment alternative to prolong the lives of patients," David Mullins said. "Something as simple as the induction of a particular chemokine receptor on T cells can translate into enhanced survival, which can be quite profound."

The discovery was made possible because of a unique combination of resources at the U.Va. Health System, including collaboration between laboratory scientists, clinicians and statisticians. David Mullins stressed that the organization of the Human Immune Therapy Center at U.Va. means that research can be brought from the lab to the clinic in a matter of days, rather than months or years. "We are quickly retargeting vaccines at U.Va. to be used in patients, taking advantage of our observations," Mullins said.

Last year, Dr. Craig Slingluff, professor of surgery at U.Va. and director of the HITC, reported that using molecules called peptides to treat melanoma resulted in an immune response from 75 percent of the patients in a phase II clinical trial of a melanoma vaccine. The vaccine was also associated with tumor regression.

Bob Beard | EurekAlert!
Further information:
http://www.virginia.edu
http://cancerres.aacrjournals.org/

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>