University of Pittsburgh researchers have identified biomarkers that could result in earlier and more accurate diagnosis of systemic lupus erythematosus (SLE), a devastating disease that affects as many as 1.5 million Americans, and occurs 10 to 15 times more frequently in women. The results are published in the November 2004 issue of Arthritis & Rheumatism.
"This is the first report of abnormal levels of the protein erythrocyte-C4d in human disease," said lead author Susan Manzi, M.D., M.P.H., associate professor of medicine, epidemiology and dermatology at the University of Pittsburgh School of Medicine and the University of Pittsburgh Graduate School of Public Health. "Abnormally high levels of erythrocyte-C4d and low levels of erythrocyte-CR1 are characteristic of SLE and combined measurement of the two proteins has high diagnostic sensitivity and specificity for lupus."
The significance of the finding is substantial, according to Joseph Ahearn, M.D., associate professor of medicine at the University of Pittsburgh School of Medicine and senior author of the study. "Today we are one step closer to providing patients with an immediate and accurate diagnosis, one step closer to providing physicians with the ability to offer better treatment options and one step closer to providing incentive to lower the cost of health care for patients suffering from lupus," Dr. Ahearn said. "Lupus is the prototypical autoimmune disease and arguably the greatest diagnostic challenge among rheumatologic diseases," he said. "The spectrum of disease among patients with SLE is broad and ranges from subtle or vague symptoms to life-threatening multiorgan failure, and the manifestations of lupus often mimic those of other diseases makes it difficult to diagnose."
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Awards Funding
26.10.2016 | Power and Electrical Engineering
26.10.2016 | Health and Medicine