Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pitt researchers identify biomarkers of lupus which could lead to quicker and better diagnosis

04.11.2004


University of Pittsburgh researchers have identified biomarkers that could result in earlier and more accurate diagnosis of systemic lupus erythematosus (SLE), a devastating disease that affects as many as 1.5 million Americans, and occurs 10 to 15 times more frequently in women. The results are published in the November 2004 issue of Arthritis & Rheumatism.



"This is the first report of abnormal levels of the protein erythrocyte-C4d in human disease," said lead author Susan Manzi, M.D., M.P.H., associate professor of medicine, epidemiology and dermatology at the University of Pittsburgh School of Medicine and the University of Pittsburgh Graduate School of Public Health. "Abnormally high levels of erythrocyte-C4d and low levels of erythrocyte-CR1 are characteristic of SLE and combined measurement of the two proteins has high diagnostic sensitivity and specificity for lupus."

The significance of the finding is substantial, according to Joseph Ahearn, M.D., associate professor of medicine at the University of Pittsburgh School of Medicine and senior author of the study. "Today we are one step closer to providing patients with an immediate and accurate diagnosis, one step closer to providing physicians with the ability to offer better treatment options and one step closer to providing incentive to lower the cost of health care for patients suffering from lupus," Dr. Ahearn said. "Lupus is the prototypical autoimmune disease and arguably the greatest diagnostic challenge among rheumatologic diseases," he said. "The spectrum of disease among patients with SLE is broad and ranges from subtle or vague symptoms to life-threatening multiorgan failure, and the manifestations of lupus often mimic those of other diseases makes it difficult to diagnose."


It is not unusual for a patient with lupus to seek advice from a variety of specialists and subspecialists over a period of years before being accurately diagnosed, which results in delays in receiving proper therapy and an ultimately greater cost for treating the disease and its complications. Although there is no cure for lupus, there are many ways to treat symptoms, including chemotherapy. Currently, most physicians rely on blood abnormalities to aid in the diagnosis of SLE, but according to Dr. Manzi, these tests are inadequate because they are not sensitive or specific enough.

In the study, researchers used blood samples taken from each participant and analyzed them using flow cytometry to compare the levels of proteins in 100 patients who were confirmed to have lupus, 133 patients who had other diseases and conditions including myositis, systemic sclerosis, hepatitis and rheumatoid arthritis, and 84 healthy patients.

Lupus is a widespread and chronic autoimmune disease that, for unknown reasons, causes the immune system to attack the body’s own tissue and organs, including the joints, kidneys, heart, lungs, brain, blood and skin. The immune system normally protects the body against viruses, bacteria and other foreign materials. In an autoimmune disease like lupus, the immune system loses its ability to tell the difference between foreign substances and its own cells and tissue. The immune system then makes antibodies directed against itself.

Alan Aldinger | EurekAlert!
Further information:
http://www.upmc.edu
http://www.lupuscenter.org

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>