Mutation indicates risk of acquiring disease
Researchers from the Samuel Lunenfeld Research Institute at Mount Sinai Hospital have determined that the mutation of a specific gene in some patients with colon cancer indicate a risk of acquiring the disease. The study appears in the Nov. 3 edition of the Journal of the National Cancer Institute. The research team, led by Dr. Steven Gallinger used a population based study to determine that when one parent had the MutY human homologue (MYH) gene and there was also a family history of acquiring the disease then it may account for a fraction of hereditary colorectal cancers.
The child of a couple that has one MYH gene carrier has a 1:2 risk of carrying the mutation and this translates into increased risk of developing the disease. "This is going to contribute to new knowledge of colon cancer and it may impact who goes for testing," said Dr. Gallinger, a researcher and surgeon. He is also a professor of surgery at the University of Toronto.
Kathy Pyatt | EurekAlert!
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