Implications for better understanding of diabetes, metabolic syndrome, and obesity
Researchers at the University of Pennsylvania School of Medicine have discovered that components of the internal molecular clock of mammals have an important role in governing the metabolism of sugars and fats within the body. They found in mice that two of the well-studied proteins in the clock control the ability of animals to recover from the fall in blood sugar that occurs in response to insulin.
The investigators demonstrate a role for the circadian clock proteins, Bmal1 and Clock, in regulating the day-to-day levels of glucose in the blood. Suppressing the action of these molecules eliminates the diurnal variation in glucose and triglyceride levels. In addition, they found that a mutated Clock gene protected mice from diabetes induced by a high-fat diet. Together these findings represent the first molecular insight into how timing of what we eat – via the clock – can influence metabolism. The findings appear in the November 2 issue of the online journal PLoS Biology.
Karen Kreeger | EurekAlert!
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